AP3S2 and SCARB2

Number of citations: 0 (PubMedID 15469849)
Data Source: BioGRID (pull down)

		AP3S2	SCARB2
Name		adaptor related protein complex 3 subunit sigma 2	scavenger receptor class B member 2
Structure		No pdb structure
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Synaptic Vesicle Membrane Membrane Coat AP-3 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Axon Cytoplasm	Golgi Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	None	Virus Receptor Activity Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Cholesterol Binding Enzyme Binding Phosphatidylcholine Binding Cargo Receptor Activity Protein Homodimerization Activity Protein-folding Chaperone Binding
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Anterograde Axonal Transport Protein Transport Synaptic Vesicle Coating Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Melanosome Assembly	Protein Targeting To Lysosome Receptor-mediated Endocytosis Sensory Perception Of Sound Positive Regulation Of Neuron Projection Development Aminophospholipid Transport Regulation Of Carbohydrate Catabolic Process Symbiont Entry Into Host Cell Endosome To Plasma Membrane Protein Transport Regulation Of Endosome Organization Regulation Of Lysosome Organization Regulation Of Glucosylceramide Catabolic Process
Pathways		None	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Diseases		None	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Type 2 diabetes ( 21874001 23945395 24509480 28869590 29358691 30054458 30297969 30718926 32499647 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 )	BMI (adjusted for smoking behaviour) ( 28443625 ) Body mass index ( 25673413 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Estimated glomerular filtration rate ( 31015462 ) Hippocampal volume ( 29274321 ) Parkinson's disease ( 21738487 25064009 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 )
Interacting Genes		7 interacting genes: AP3B1 AP3D1 AP3S1 ARF1 ARF6 E2F4 SCARB2	10 interacting genes: AP3S1 AP3S2 CLDN19 ERGIC3 GPR37L1 GPX8 HIBADH LAPTM4B LMNA THBS1
Entrez ID		10239	950
HPRD ID		03880	03772
Ensembl ID		ENSG00000157823	ENSG00000138760
Uniprot IDs		P59780	A0A1W2PRF6 Q14108
PDB IDs		Not available	4F7B 4Q4B 4Q4F 4TVZ 4TW0 4TW2 5UPH 5XBM 6I2K
GO Terms Enriched among Interactors		Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Intracellular Protein Transport AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Melanosome Assembly Platelet Dense Granule Organization Membrane Coat Vesicle Cargo Loading Vacuolar Transport Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Protein Transport Vesicle-mediated Transport Vesicle Transport Along Microtubule Anterograde Axonal Transport Intracellular Transport Protein Targeting To Vacuole Positive Regulation Of NK T Cell Differentiation Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Protein Localization To Lysosome Synaptic Vesicle Coating Axon Cytoplasm Establishment Of Protein Localization To Vacuole Axonal Transport Secretory Granule Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of NK T Cell Differentiation Cellular Localization Establishment Of Localization In Cell Axo-dendritic Transport Early Endosome Organelle Transport Along Microtubule Protein Localization To Vacuole Intracellular Protein Localization Establishment Of Vesicle Localization Vesicle Localization Lysosomal Transport Synaptic Vesicle Recycling Organelle Localization Golgi To Vacuole Transport Localization Within Membrane Transport Along Microtubule Golgi Apparatus Cytoskeleton-dependent Intracellular Transport Protein Targeting Protein Localization To Organelle Protein Localization To Cell Surface Protein Targeting To Lysosome	Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Coating AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Synaptic Vesicle Recycling Melanosome Assembly Golgi To Vacuole Transport Platelet Dense Granule Organization Membrane Coat Vesicle Cargo Loading Synaptic Vesicle Transport Vesicle Coating Melanosome Organization Pigment Granule Organization Vesicle Transport Along Microtubule Anterograde Axonal Transport Intracellular Transport Establishment Of Organelle Localization Vesicle Cytoskeletal Trafficking Golgi Vesicle Transport Axon Cytoplasm 3-hydroxyisobutyrate Dehydrogenase Activity Axonal Transport Vesicle Organization Secretory Granule Organization Early Endosome Cellular Localization Axo-dendritic Transport Establishment Of Localization In Cell Organelle Transport Along Microtubule DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Nitric Oxide Mediated Signal Transduction Collagen V Binding Prosaposin Receptor Activity Retrograde Transporter Complex, Golgi To ER Regulation Of Lysosomal Membrane Permeability Mesaxon Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Organelle Localization Vesicle Localization Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Transporter Complex Regulation Of Transepithelial Transport AP-type Membrane Coat Adaptor Complex