AP3S2 and AP3B1

Number of citations: 0 (PubMedID 9182526)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		AP3S2	AP3B1
Name		adaptor related protein complex 3 subunit sigma 2	adaptor related protein complex 3 subunit beta 1
Structure		No pdb structure
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Synaptic Vesicle Membrane Membrane Coat AP-3 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Axon Cytoplasm	Mitochondrion Lysosomal Membrane Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Axon Cytoplasm Microvesicle
	Molecular Function	None	Protein Binding Protein Phosphatase Binding GTP-dependent Protein Binding
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Anterograde Axonal Transport Protein Transport Synaptic Vesicle Coating Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Melanosome Assembly	Cell Morphogenesis Toll-like Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Respiratory System Process Protein Targeting Protein Targeting To Lysosome Intracellular Zinc Ion Homeostasis Intracellular Protein Transport Inflammatory Response Lysosome Organization Spermatogenesis Single Fertilization Blood Coagulation Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Lung Development Granulocyte Differentiation Melanosome Organization Protein Localization To Cell Surface Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Protein Modification Process MRNA Transcription By RNA Polymerase II Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Lung Morphogenesis Membrane Organization Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Skin Epidermis Development Melanosome Assembly
Pathways		None	Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF1 fusions
Diseases		None	Hermansky-Pudlak syndrome (HPS)
GWAS		Type 2 diabetes ( 21874001 23945395 24509480 28869590 29358691 30054458 30297969 30718926 32499647 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 )	Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Body size at age 10 ( 32376654 ) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697 ) FEV1 ( 30804560 ) Hip circumference adjusted for BMI ( 34021172 ) Insulin resistance/response ( 21901158 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lung function (FEV1) ( 30061609 ) Lung function (FVC) ( 30061609 30804560 ) Metabolite levels ( 23823483 ) Red cell distribution width ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Triglycerides ( 26780889 ) Type 2 diabetes ( 31049640 )
Novel Interactors		None recorded	5 novel interactors: CXADR FCGR2B RNGTT SSBP2 ZER1
Interacting Genes		7 interacting genes: AP3B1 AP3D1 AP3S1 ARF1 ARF6 E2F4 SCARB2	13 interacting genes: AP3S2 ARF1 ARF5 ARF6 ARR3 ATM ATR BUB1 BUB1B CLTC CSNK1A1 GKAP1 SLC30A3
Entrez ID		10239	8546
HPRD ID		03880	04551
Ensembl ID		ENSG00000157823	ENSG00000132842
Uniprot IDs		P59780	A0A0S2Z5J4 A0A8Q3SIM7 O00203
PDB IDs		Not available	9C58 9C59 9C5A 9C5B 9C5C
GO Terms Enriched among Interactors		Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Intracellular Protein Transport AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Melanosome Assembly Platelet Dense Granule Organization Membrane Coat Vesicle Cargo Loading Vacuolar Transport Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Protein Transport Vesicle-mediated Transport Vesicle Transport Along Microtubule Anterograde Axonal Transport Intracellular Transport Protein Targeting To Vacuole Positive Regulation Of NK T Cell Differentiation Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Protein Localization To Lysosome Synaptic Vesicle Coating Axon Cytoplasm Establishment Of Protein Localization To Vacuole Axonal Transport Secretory Granule Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of NK T Cell Differentiation Cellular Localization Establishment Of Localization In Cell Axo-dendritic Transport Early Endosome Organelle Transport Along Microtubule Protein Localization To Vacuole Intracellular Protein Localization Establishment Of Vesicle Localization Vesicle Localization Lysosomal Transport Synaptic Vesicle Recycling Organelle Localization Golgi To Vacuole Transport Localization Within Membrane Transport Along Microtubule Golgi Apparatus Cytoskeleton-dependent Intracellular Transport Protein Targeting Protein Localization To Organelle Protein Localization To Cell Surface Protein Targeting To Lysosome	Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Histone H2AXS139 Kinase Activity Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Mitotic Nuclear Division Nucleotide Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Mitotic Sister Chromatid Separation Protein Serine/threonine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Meiotic Sister Chromatid Cohesion Negative Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Cell Division Negative Regulation Of Cell Cycle Phase Transition Spindle DNA Strand Resection Involved In Replication Fork Processing Vesicle-mediated Transport Regulation Of Chromosome Organization Replicative Senescence Regulation Of Cellular Response To Heat Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Organelle Organization Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Kinase Activity Negative Regulation Of B Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Chromosome Organization Intracellular Protein Transport Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Outer Kinetochore Intracellular Protein Localization Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Segregation Kinase Activity Protein Localization To Site Of Double-strand Break Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Cellular Response To Gamma Radiation Chromosome Organization