KLK1 and A2M

Number of citations of the paper that reports this interaction (PubMedID 3643793)
20

Data Source:
BioGRID (pull down)

		KLK1	A2M
Description		kallikrein 1	alpha-2-macroglobulin
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Secretory Granule Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation	Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Developmental Lineage of Pancreatic Acinar Cells	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly
Drugs		Aluminium Benzamidine Lanoteplase Aprotinin Aniline Nafamostat Aluminium phosphate Aluminum acetate	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)	Refractive error ( 32231278)
Interacting Genes		8 interacting genes: A2M ITIH4 KNG1 PROC SERPINA1 SERPINA4 SERPINA5 SERPINC1	99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40
Entrez ID		3816	2
HPRD ID		01003	00072
Ensembl ID		ENSG00000167748	ENSG00000175899
Uniprot IDs		A0A1R3UCD2 P06870	P01023
PDB IDs		1SPJ 8YGY	1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO
Enriched GO Terms of Interacting Partners?		Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Extracellular Space Extracellular Matrix Extracellular Region Protease Binding Coagulation Blood Coagulation Hemostasis Blood Microparticle Extracellular Exosome Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Platelet Dense Granule Lumen Regulation Of Wound Healing Heparin Binding Regulation Of Response To Wounding Acute-phase Response Endopeptidase Inhibitor Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Acute Inflammatory Response Negative Regulation Of Wound Healing Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Negative Regulation Of Complement Activation, Lectin Pathway Seminal Clot Liquefaction Interleukin-8 Binding Platelet Dense Tubular Network Inflammatory Response Acrosin Binding Positive Regulation Of Establishment Of Endothelial Barrier Tumor Necrosis Factor Binding Interleukin-1 Binding Negative Regulation Of Complement Activation Negative Regulation Of Defense Response Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Regulation Of Establishment Of Endothelial Barrier	Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process
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