KLK1 and SERPINA4

Number of citations of the paper that reports this interaction (PubMedID 10862973)
0

Data Source:
HPRD (in vitro)

		KLK1	SERPINA4
Description		kallikrein 1	serpin family A member 4
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Secretory Granule Extracellular Exosome	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Developmental Lineage of Pancreatic Acinar Cells	Platelet degranulation Developmental Lineage of Pancreatic Acinar Cells
Drugs		Aluminium Benzamidine Lanoteplase Aprotinin Aniline Nafamostat Aluminium phosphate Aluminum acetate	Zinc Copper Zinc acetate
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)	Blood protein levels ( 30072576) Vaspin levels ( 22907691)
Interacting Genes		8 interacting genes: A2M ITIH4 KNG1 PROC SERPINA1 SERPINA4 SERPINA5 SERPINC1	14 interacting genes: CFTR CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1
Entrez ID		3816	5267
HPRD ID		01003	01004
Ensembl ID		ENSG00000167748	ENSG00000100665
Uniprot IDs		A0A1R3UCD2 P06870	A0A024R6I9 P29622
PDB IDs		1SPJ 8YGY	6F02
Enriched GO Terms of Interacting Partners?		Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Extracellular Space Extracellular Matrix Extracellular Region Protease Binding Coagulation Blood Coagulation Hemostasis Blood Microparticle Extracellular Exosome Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Platelet Dense Granule Lumen Regulation Of Wound Healing Heparin Binding Regulation Of Response To Wounding Acute-phase Response Endopeptidase Inhibitor Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Acute Inflammatory Response Negative Regulation Of Wound Healing Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Negative Regulation Of Complement Activation, Lectin Pathway Seminal Clot Liquefaction Interleukin-8 Binding Platelet Dense Tubular Network Inflammatory Response Acrosin Binding Positive Regulation Of Establishment Of Endothelial Barrier Tumor Necrosis Factor Binding Interleukin-1 Binding Negative Regulation Of Complement Activation Negative Regulation Of Defense Response Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Regulation Of Establishment Of Endothelial Barrier
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?