KLK1 and SERPINA4

Number of citations of the paper that reports this interaction (PMID 11016932)
9

Data Source:
HPRD (in vitro)

		KLK1	SERPINA4
Gene Name		kallikrein 1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Extracellular Vesicular Exosome	Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis	Negative Regulation Of Endopeptidase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Aprotinin
Diseases
GWAS			Vaspin levels ( 22907691)
Protein-Protein Interactions		3 interactors: KNG1 SERPINA4 SERPINA5	13 interactors: CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1D1
Entrez ID		3816	5267
HPRD ID		01003	01004
Ensembl ID		ENSG00000167748	ENSG00000100665
Uniprot IDs		F8WAM8 P06870	P29622
PDB IDs		1SPJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Regulation Of Catalytic Activity Positive Regulation Of Renal Sodium Excretion Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Urine Volume Blood Coagulation, Intrinsic Pathway Fusion Of Sperm To Egg Plasma Membrane Plasma Membrane Fusion Response To Wounding Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Smooth Muscle Contraction Negative Regulation Of Wound Healing Platelet Degranulation Regulation Of Blood Vessel Size Regulation Of Tube Size Renal System Process Regulation Of Blood Coagulation Membrane Fusion Regulation Of Wound Healing Single Fertilization Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Protein Activation Cascade Fertilization Cytosolic Calcium Ion Homeostasis Platelet Activation	Activation Of MAPKKK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Activation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Signal Transduction By Phosphorylation Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cellular Metabolic Process JNK Cascade Extracellular Matrix Disassembly Regulation Of Intracellular Signal Transduction Stress-activated MAPK Cascade Regulation Of Cell-matrix Adhesion Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Locomotion Positive Regulation Of Signal Transduction Immune System Process Immune Response Regulation Of JNK Cascade Regulation Of Cell Adhesion Defense Response
Tagcloud ?		b2 bradykinin cancers diverse du145 emanating endometrial enzymic exhibit expressed implicated kallikrein kinin lncap member members organs particular prostate proteases range reproductive serine structurally tissue tumorigenesis uterus varying	academic bcl2 beadchip caucasian cohorts complicates diego discovery entirely genotyped genotyping hundred illumina injury kallistatin kidney nucleotide polymorphisms predicts rs12457893 rs8094315 san septic shock sixty split tertiary thousand validation
Tagcloud (Difference) ?		b2 bradykinin cancers diverse du145 emanating endometrial enzymic exhibit expressed implicated kallikrein kinin lncap member members organs particular prostate proteases range reproductive serine structurally tissue tumorigenesis uterus varying	academic bcl2 beadchip caucasian cohorts complicates diego discovery entirely genotyped genotyping hundred illumina injury kallistatin kidney nucleotide polymorphisms predicts rs12457893 rs8094315 san septic shock sixty split tertiary thousand validation
Tagcloud (Intersection) ?