KLK1

Description		kallikrein 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Secretory Granule Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Developmental Lineage of Pancreatic Acinar Cells
Drugs		Aluminium Benzamidine Lanoteplase Aprotinin Aniline Nafamostat Aluminium phosphate Aluminum acetate
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		8 interacting genes: A2M ITIH4 KNG1 PROC SERPINA1 SERPINA4 SERPINA5 SERPINC1
Entrez ID		3816
HPRD ID		01003
Ensembl ID		ENSG00000167748
Uniprot IDs		A0A1R3UCD2 P06870
PDB IDs		1SPJ 8YGY
Enriched GO Terms of Interacting Partners?		Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Extracellular Space Extracellular Matrix Extracellular Region Protease Binding Coagulation Blood Coagulation Hemostasis Blood Microparticle Extracellular Exosome Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Platelet Dense Granule Lumen Regulation Of Wound Healing Heparin Binding Regulation Of Response To Wounding Acute-phase Response Endopeptidase Inhibitor Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Acute Inflammatory Response Negative Regulation Of Wound Healing Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Negative Regulation Of Complement Activation, Lectin Pathway Seminal Clot Liquefaction Interleukin-8 Binding Platelet Dense Tubular Network Inflammatory Response Acrosin Binding Positive Regulation Of Establishment Of Endothelial Barrier Tumor Necrosis Factor Binding Interleukin-1 Binding Negative Regulation Of Complement Activation Negative Regulation Of Defense Response Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Regulation Of Establishment Of Endothelial Barrier
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