KLK1 and SERPINC1

Number of citations of the paper that reports this interaction (PubMedID 3643793)
20

Data Source:
BioGRID (pull down)

		KLK1	SERPINC1
Description		kallikrein 1	serpin family C member 1
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GO Annotations	Cellular Component	Extracellular Space Nucleus Secretory Granule Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation	Blood Coagulation Hemostasis Regulation Of Blood Coagulation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Developmental Lineage of Pancreatic Acinar Cells	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Aluminium Benzamidine Lanoteplase Aprotinin Aniline Nafamostat Aluminium phosphate Aluminum acetate	Ardeparin Fondaparinux Heparin Enoxaparin N-Formylmethionine SR-123781A Sulodexide Danaparoid Dalteparin Tinzaparin Nadroparin Copper Protamine sulfate Bemiparin Antithrombin III human
Diseases			Inherited thrombophilia
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)	Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549)
Interacting Genes		8 interacting genes: A2M ITIH4 KNG1 PROC SERPINA1 SERPINA4 SERPINA5 SERPINC1	7 interacting genes: F2 HSP90AA1 KLK1 KLK2 KLK6 PLG SDC2
Entrez ID		3816	462
HPRD ID		01003	00122
Ensembl ID		ENSG00000167748	ENSG00000117601
Uniprot IDs		A0A1R3UCD2 P06870	P01008
PDB IDs		1SPJ 8YGY	1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
Enriched GO Terms of Interacting Partners?		Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Extracellular Space Extracellular Matrix Extracellular Region Protease Binding Coagulation Blood Coagulation Hemostasis Blood Microparticle Extracellular Exosome Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Platelet Dense Granule Lumen Regulation Of Wound Healing Heparin Binding Regulation Of Response To Wounding Acute-phase Response Endopeptidase Inhibitor Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Acute Inflammatory Response Negative Regulation Of Wound Healing Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Negative Regulation Of Complement Activation, Lectin Pathway Seminal Clot Liquefaction Interleukin-8 Binding Platelet Dense Tubular Network Inflammatory Response Acrosin Binding Positive Regulation Of Establishment Of Endothelial Barrier Tumor Necrosis Factor Binding Interleukin-1 Binding Negative Regulation Of Complement Activation Negative Regulation Of Defense Response Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Regulation Of Establishment Of Endothelial Barrier	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Protein Processing Peptidase Activity Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Space Secretory Granule Regulation Of Fibrinolysis Fibrinolysis Protein Maturation MHC Class II Protein Complex Binding Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Biological Quality Biological Process Involved In Interaction With Symbiont Zymogen Activation Protein Metabolic Process Negative Regulation Of Coagulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Extracellular Region Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Albendazole Monooxygenase Activity CTP Binding DATP Binding Regulation Of Systemic Arterial Blood Pressure Tissue Regeneration Hydrolase Activity Cellular Homeostasis Protein Transport Into Plasma Membrane Raft Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Endoplasmic Reticulum Lumen Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Platelet Alpha Granule Lumen Proteolysis Regulation Of Cardiac Muscle Contraction Striated Muscle Contraction Endopeptidase Activity Rho GDP-dissociation Inhibitor Binding Lysosomal Lumen Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Flavin-dependent Sulfhydryl Oxidase Activity
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