KLK1 and SERPINA5

Number of citations of the paper that reports this interaction (PMID 9368023)
8

Data Source:
HPRD (in vitro)

		KLK1	SERPINA5
Gene Name		kallikrein 1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Extracellular Vesicular Exosome	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein Complex Extracellular Vesicular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex
	Molecular Function	Serine-type Endopeptidase Activity	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding
	Biological Process	Proteolysis	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Blood Coagulation Negative Regulation Of Endopeptidase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Aprotinin
Diseases
GWAS
Protein-Protein Interactions		3 interactors: KNG1 SERPINA4 SERPINA5	20 interactors: ACR COPS6 F10 F11 F2 FGA FGB FGG HRSP12 KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 SEMG2 THBD
Entrez ID		3816	5104
HPRD ID		01003	03503
Ensembl ID		ENSG00000167748	ENSG00000188488
Uniprot IDs		F8WAM8 P06870	B3KTV6 B4DDH1 B4DPC7 P05154
PDB IDs		1SPJ	1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Regulation Of Catalytic Activity Positive Regulation Of Renal Sodium Excretion Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Urine Volume Blood Coagulation, Intrinsic Pathway Fusion Of Sperm To Egg Plasma Membrane Plasma Membrane Fusion Response To Wounding Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Smooth Muscle Contraction Negative Regulation Of Wound Healing Platelet Degranulation Regulation Of Blood Vessel Size Regulation Of Tube Size Renal System Process Regulation Of Blood Coagulation Membrane Fusion Regulation Of Wound Healing Single Fertilization Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Protein Activation Cascade Fertilization Cytosolic Calcium Ion Homeostasis Platelet Activation	Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Blood Coagulation Hemostasis Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Plasminogen Activation Fibrinolysis Proteolysis Protein Activation Cascade Positive Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Peptidyl-glutamic Acid Carboxylation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Endothelial Cell Apoptotic Process Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Zymogen Activation Factor XII Activation Positive Regulation Of Vasoconstriction Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Stress Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Vasoconstriction Platelet Activation Positive Regulation Of Exocytosis Regulation Of Cell-substrate Adhesion Platelet Degranulation Negative Regulation Of Fibrinolysis Acute Inflammatory Response Plasma Kallikrein-kinin Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Peptide Hormone Secretion Protein Processing Positive Regulation Of Peptide Secretion Extracellular Matrix Disassembly Protein Polymerization Positive Regulation Of Hormone Secretion Negative Regulation Of Platelet Activation Response To Calcium Ion
Tagcloud ?		b2 bradykinin cancers diverse du145 emanating endometrial enzymic exhibit expressed implicated kallikrein kinin lncap member members organs particular prostate proteases range reproductive serine structurally tissue tumorigenesis uterus varying	across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Difference) ?		b2 bradykinin cancers diverse du145 emanating endometrial enzymic exhibit expressed implicated kallikrein kinin lncap member members organs particular prostate proteases range reproductive serine structurally tissue tumorigenesis uterus varying	across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Intersection) ?