CISH and CSF3R

Number of citations of the paper that reports this interaction (PMID 15470047)
10

Data Source:
HPRD (in vitro, in vivo)

		CISH	CSF3R
Gene Name		cytokine inducible SH2-containing protein	colony stimulating factor 3 receptor (granulocyte)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm Cytosol Plasma Membrane	Extracellular Region Integral Component Of Plasma Membrane
	Molecular Function	Molecular_function Protein Kinase Inhibitor Activity Protein Binding	Receptor Activity Cytokine Receptor Activity Protein Binding
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Protein Kinase Activity Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Defense Response Cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Amelogenesis
Pathways		Cytokine Signaling in Immune system Growth hormone receptor signaling
Drugs			Pegfilgrastim Filgrastim
Diseases
GWAS
Protein-Protein Interactions		18 interactors: CSF2RB CSF3R EGFR EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2	19 interactors: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2
Entrez ID		1154	1441
HPRD ID		03897	00737
Ensembl ID		ENSG00000114737	ENSG00000119535
Uniprot IDs		Q9NSE2	Q99062
PDB IDs			1AZ7 2D9Q
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Cytokine Stimulus Cellular Response To Stimulus Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Protein Phosphorylation Phosphorylation Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of MAPK Cascade Histone H3-T6 Phosphorylation Erythropoietin-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Activation Of JAK2 Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Response To Growth Factor Chemotaxis Negative Regulation Of Cell Death Cellular Response To Erythropoietin Regulation Of MAPK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Response To Interleukin-3 Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cell Activation Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway	Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Immune Response Leukocyte Migration Regulation Of Immune Response Response To Peptide Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Immune System Process Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Motility Immune System Process Defense Response Innate Immune Response Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Organonitrogen Compound Response To Organic Substance Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Locomotion Response To Hormone Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Growth Hormone Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction JAK-STAT Cascade Blood Coagulation Hemostasis Regulation Of Intracellular Signal Transduction Signal Transduction Cytokine-mediated Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus
Tagcloud ?		adenocarcinomas applicable appropriately chromogenic clinicopathologic differentiating diffuse disagreement educated esophageal gastroesophageal her2 histologically ihc interobserver introduced junction oncogene pathologists positivity retrieved retrospectively scoring stained standardized trained validate variability	1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f
Tagcloud (Difference) ?		adenocarcinomas applicable appropriately chromogenic clinicopathologic differentiating diffuse disagreement educated esophageal gastroesophageal her2 histologically ihc interobserver introduced junction oncogene pathologists positivity retrieved scoring stained standardized trained validate variability	1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol reviewed sequenced setbp1 significance suspected twelve uncertain v617f
Tagcloud (Intersection) ?		retrospectively