CISH and CSF2RB

Number of citations of the paper that reports this interaction (PMID 7796808)
97

Data Source:
HPRD (in vitro)

		CISH	CSF2RB
Gene Name		cytokine inducible SH2-containing protein	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm Cytosol Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
	Molecular Function	Molecular_function Protein Kinase Inhibitor Activity Protein Binding	Receptor Activity Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Protein Kinase Activity Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Signal Transduction Respiratory Gaseous Exchange Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway
Pathways		Cytokine Signaling in Immune system Growth hormone receptor signaling	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: CSF2RB CSF3R EGFR EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2	27 interactors: CISH CSF2 CSF2RA EPOR FES FYN GNB2L1 HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 SHC1 STAT1 STAT3 SYK YWHAZ
Entrez ID		1154	1439
HPRD ID		03897	00739
Ensembl ID		ENSG00000114737	ENSG00000100368
Uniprot IDs		Q9NSE2	B4DZL8 P32927 Q6NSJ8
PDB IDs			1C8P 1EGJ 1GH7 2GYS 3CXE
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Cytokine Stimulus Cellular Response To Stimulus Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Protein Phosphorylation Phosphorylation Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of MAPK Cascade Histone H3-T6 Phosphorylation Erythropoietin-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Activation Of JAK2 Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Response To Growth Factor Chemotaxis Negative Regulation Of Cell Death Cellular Response To Erythropoietin Regulation Of MAPK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Response To Interleukin-3 Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cell Activation Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Organic Substance Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Immune Response Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Response To Cytokine Immune System Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Defense Response Regulation Of Immune Response Cellular Response To Peptide Hormone Stimulus Protein Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Innate Immune Response Regulation Of Immune System Process Regulation Of JAK-STAT Cascade Regulation Of Signal Transduction JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Peptidyl-amino Acid Modification Signal Transduction Cellular Response To Growth Hormone Stimulus Regulation Of Cell Proliferation Cellular Response To Hormone Stimulus Intracellular Signal Transduction Regulation Of Signaling Response To Peptide Hormone Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cell Migration Signaling Response To Peptide Cell Communication Leukocyte Migration Cellular Response To Stimulus Cell Motility Response To Growth Hormone Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cellular Amino Acid Metabolic Process Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
Tagcloud ?		adenocarcinomas applicable appropriately chromogenic clinicopathologic differentiating diffuse disagreement educated esophageal gastroesophageal her2 histologically ihc interobserver introduced junction oncogene pathologists positivity retrieved retrospectively scoring stained standardized trained validate variability	11b affymetrix arrayed ccl2 ccl7 cdkn1a copg custom cxcl1 defining fourteen genechip glioma gliomas gliosarcomas grades icam igfbp immunotherapy portend saa4 sag sags senescence signature tnfrsf tnfsf translating u133
Tagcloud (Difference) ?		adenocarcinomas applicable appropriately chromogenic clinicopathologic differentiating diffuse disagreement educated esophageal gastroesophageal her2 histologically ihc interobserver introduced junction oncogene pathologists positivity retrieved retrospectively scoring stained standardized trained validate variability	11b affymetrix arrayed ccl2 ccl7 cdkn1a copg custom cxcl1 defining fourteen genechip glioma gliomas gliosarcomas grades icam igfbp immunotherapy portend saa4 sag sags senescence signature tnfrsf tnfsf translating u133
Tagcloud (Intersection) ?