ITGAV and TGM2

Number of citations of the paper that reports this interaction (PubMedID 19542224)
57

Data Source:
BioGRID (pull down)

		ITGAV	TGM2
Description		integrin subunit alpha V	transglutaminase 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta1 Complex Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta6 Complex Integrin Alphav-beta8 Complex Specific Granule Membrane Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Phagocytic Vesicle Extracellular Exosome Anchoring Junction	Chromatin Nucleosome Extracellular Region Nucleus Chromosome Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Signaling Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Signaling Receptor Activity Neuregulin Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding	Nucleotide Binding Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Protein-glutamine Glutaminase Activity Peptide Serotonyltransferase Activity Histone Serotonyltransferase Activity Peptide Dopaminyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Formation Of Primary Germ Layer Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Tissue Development Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Cell Adhesion Mediated By Integrin Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Symbiont Entry Into Host Cell Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Negative Chemotaxis Positive Regulation Of Small GTPase Mediated Signal Transduction ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Transforming Growth Factor Beta Production Entry Into Host Cell By A Symbiont-containing Vacuole Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Chromatin Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Gene Expression Dopamine Secretion Peptide Cross-linking Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Positive Regulation Of Sprouting Angiogenesis Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance
Pathways		Cross-presentation of particulate exogenous antigens (phagosomes) Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Laminin interactions Syndecan interactions Syndecan interactions ECM proteoglycans VEGFA-VEGFR2 Pathway Signal transduction by L1 Neutrophil degranulation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Antithymocyte immunoglobulin (rabbit) Levothyroxine PLN-74809	Guanosine-5'-Diphosphate Hexylresorcinol
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Left-handedness ( 32989287) Lung function (FEV1/FVC) ( 30804560) Microalbuminuria ( 26631737) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		38 interacting genes: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CCN1 CCN3 CD47 COL11A1 COL18A1 COL6A1 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM LGALS3BP MAPK3 MMP14 MMP2 NID1 P2RY2 PAK4 PDGFRA PLA2G2A PLP1 PTK2 PXN SPP1 TGFB1 TGM2 THY1 UBC VTN	72 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 COL11A1 COL18A1 COL1A1 COL4A1 COL6A1 CSNK2A2 EIF5A FN1 FNDC3B FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HMGB1 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGAV ITGB1 ITGB3 KPNA3 KPNA4 LACRT LAMA1 LTBP1 MAP3K12 MMP14 PAK1 PELI2 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SNCA SPARC TAB2 THBS1 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		3685	7052
HPRD ID		01903	01825
Ensembl ID		ENSG00000138448	ENSG00000198959
Uniprot IDs		L7RXH0 P06756	B4DIT7 B4DTN7 P21980
PDB IDs		1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU 6AVQ 6AVR 6AVU 6DJP 6MK0 6MSL 6MSU 6NAJ 6OM1 6OM2 6UJA 6UJB 6UJC 7Y1T 8IJ5 8TCF 8TCG 8VS6 8VSD 8W30 8XEI 8XEK 8XEL 8XEN 8XER 8XEZ 8XF6 8XFG 8XFO 9CZ7 9CZA 9CZD 9CZF 9IND	1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB 8TR9 9BC2 9BC3 9BC4
Enriched GO Terms of Interacting Partners?		Integrin Binding Cell Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Focal Adhesion Extracellular Matrix Positive Regulation Of Cell Migration Cell-matrix Adhesion Positive Regulation Of Cell Motility Cell-substrate Adhesion Positive Regulation Of Locomotion Angiogenesis Cell-cell Adhesion Cell Migration Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Migration Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Cell Surface Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Binding Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Extracellular Region Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Multicellular Organismal Process Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Migration Regulation Of Cell-substrate Adhesion Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Extracellular Exosome Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Multicellular Organismal Process Integrin Complex Developmental Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Response To Mechanical Stimulus Positive Regulation Of Cell-substrate Adhesion Cellular Developmental Process Cell Differentiation Extracellular Space Positive Regulation Of Fibroblast Migration	Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Oxidative Stress Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Protease Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Extracellular Matrix Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Differentiation Regulation Of Cell Migration Signal Transduction Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Extracellular Space Regulation Of Cell Motility Regulation Of Defense Response Apolipoprotein A-I-mediated Signaling Pathway Response To Reactive Oxygen Species C3HC4-type RING Finger Domain Binding Response To External Biotic Stimulus Blood Microparticle Positive Regulation Of Cell Differentiation Focal Adhesion Regulation Of Immune System Process Response To Lipid Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Response To Hormone Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Extracellular Region Regulation Of Apoptotic Signaling Pathway Enzyme Binding Regulation Of Phosphorus Metabolic Process
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