ITGAV and L1CAM

Number of citations of the paper that reports this interaction (PubMedID 10871287)
65

Data Source:
HPRD (in vitro, in vivo)

		ITGAV	L1CAM
Description		integrin subunit alpha V	L1 cell adhesion molecule
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta1 Complex Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta6 Complex Integrin Alphav-beta8 Complex Specific Granule Membrane Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Phagocytic Vesicle Extracellular Exosome Anchoring Junction	Plasma Membrane Focal Adhesion Cell Surface Membrane Axon Dendrite Growth Cone Extracellular Matrix Cell Projection Neuronal Cell Body Axonal Growth Cone
	Molecular Function	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Signaling Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Signaling Receptor Activity Neuregulin Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding	Protein Binding Axon Guidance Receptor Activity Protein Domain Specific Binding
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Formation Of Primary Germ Layer Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Tissue Development Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Cell Adhesion Mediated By Integrin Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Symbiont Entry Into Host Cell Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Negative Chemotaxis Positive Regulation Of Small GTPase Mediated Signal Transduction ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Transforming Growth Factor Beta Production Entry Into Host Cell By A Symbiont-containing Vacuole Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Nervous System Development Axon Guidance Cell Migration Cell Differentiation Neuron Projection Development Positive Regulation Of Axon Extension Synapse Organization Axon Development
Pathways		Cross-presentation of particulate exogenous antigens (phagosomes) Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Laminin interactions Syndecan interactions Syndecan interactions ECM proteoglycans VEGFA-VEGFR2 Pathway Signal transduction by L1 Neutrophil degranulation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Basigin interactions L1CAM interactions L1CAM interactions Recycling pathway of L1 Recycling pathway of L1 Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Signal transduction by L1
Drugs		Antithymocyte immunoglobulin (rabbit) Levothyroxine PLN-74809	Ethanol
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum Hereditary spastic paraplegia (SPG)
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Left-handedness ( 32989287) Lung function (FEV1/FVC) ( 30804560) Microalbuminuria ( 26631737) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		38 interacting genes: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CCN1 CCN3 CD47 COL11A1 COL18A1 COL6A1 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM LGALS3BP MAPK3 MMP14 MMP2 NID1 P2RY2 PAK4 PDGFRA PLA2G2A PLP1 PTK2 PXN SPP1 TGFB1 TGM2 THY1 UBC VTN	24 interacting genes: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR FGFR1 ITGA5 ITGAV LINC00839 MSN NCAM1 NCAN NRP1 NRP2 NUMB PEA15 PLXNA1 PLXNB1 PRNP RANBP9 RDX RPS6KA1 RPS6KA2
Entrez ID		3685	3897
HPRD ID		01903	02394
Ensembl ID		ENSG00000138448	ENSG00000198910
Uniprot IDs		L7RXH0 P06756	P32004
PDB IDs		1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU 6AVQ 6AVR 6AVU 6DJP 6MK0 6MSL 6MSU 6NAJ 6OM1 6OM2 6UJA 6UJB 6UJC 7Y1T 8IJ5 8TCF 8TCG 8VS6 8VSD 8W30 8XEI 8XEK 8XEL 8XEN 8XER 8XEZ 8XF6 8XFG 8XFO 9CZ7 9CZA 9CZD 9CZF 9IND	8AFO 8AFP
Enriched GO Terms of Interacting Partners?		Integrin Binding Cell Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Focal Adhesion Extracellular Matrix Positive Regulation Of Cell Migration Cell-matrix Adhesion Positive Regulation Of Cell Motility Cell-substrate Adhesion Positive Regulation Of Locomotion Angiogenesis Cell-cell Adhesion Cell Migration Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Migration Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Cell Surface Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Binding Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Extracellular Region Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Multicellular Organismal Process Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Migration Regulation Of Cell-substrate Adhesion Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Extracellular Exosome Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Multicellular Organismal Process Integrin Complex Developmental Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Response To Mechanical Stimulus Positive Regulation Of Cell-substrate Adhesion Cellular Developmental Process Cell Differentiation Extracellular Space Positive Regulation Of Fibroblast Migration	Postsynaptic Membrane Semaphorin Receptor Complex Semaphorin Receptor Activity Cell Projection Organization Regulation Of Cellular Component Organization Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Hypothalamus Cell Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Signal Transduction Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Positive Regulation Of Protein Localization To Endosome Glutamatergic Synapse Cell Adhesion Focal Adhesion Cell Migration Neuron Migration Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Regulation Of Early Endosome To Late Endosome Transport Regulation Of Protein Metabolic Process Neuron Projection Development Regulation Of Transport Regulation Of Cell Migration ATPase Binding Regulation Of Cell Motility Ventral Trunk Neural Crest Cell Migration Apical Part Of Cell Cell Motility Regulation Of Cell Communication Regulation Of Locomotion Cell Adhesion Molecule Binding Microvillus Membrane Gland Morphogenesis Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Intracellular Signal Transduction Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Axon Guidance Regulation Of Anatomical Structure Morphogenesis Basolateral Plasma Membrane Membrane To Membrane Docking
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