ITGAV and ITGB8

Number of citations of the paper that reports this interaction (PMID 1918072)
33

Data Source:
HPRD (in vivo)

		ITGAV	ITGB8
Gene Name		integrin, alpha V	integrin, beta 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta8 Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Phagocytic Vesicle Extracellular Vesicular Exosome	Plasma Membrane Integrin Complex Cell Surface Integrin Alphav-beta8 Complex Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Voltage-gated Calcium Channel Activity Protein Binding Insulin-like Growth Factor I Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding	Receptor Activity Receptor Binding Extracellular Matrix Protein Binding
	Biological Process	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Cell Growth Cell Migration Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Apoptotic Cell Clearance Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Cell Adhesion Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Leukocyte Migration Negative Chemotaxis Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Cell Clearance Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Ganglioside Metabolic Process Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Matrix Organization Cartilage Development Placenta Blood Vessel Development
Pathways		Signal transduction by L1 Axon guidance Elastic fibre formation L1CAM interactions Non-integrin membrane-ECM interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Laminin interactions Signaling by VEGF ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System	Molecules associated with elastic fibres Elastic fibre formation Integrin cell surface interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CD47 CYR61 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM MMP14 MMP2 NID1 NOV P2RY2 PAK4 PDGFRA PLP1 PTK2 SPP1 TGFB1 THY1	3 interactors: ITGAV TGFB1 VTN
Entrez ID		3685	3696
HPRD ID		01903	05001
Ensembl ID		ENSG00000138448	ENSG00000105855
Uniprot IDs		B7ZLX0 P06756	B4DHD4 P26012 Q9BUG9
PDB IDs		1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-matrix Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Locomotion Regulation Of Cell-substrate Adhesion Cardiovascular System Development Blood Vessel Development Response To External Stimulus Vasculature Development Single Organismal Cell-cell Adhesion Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Developmental Process Blood Vessel Morphogenesis Cell Migration Tissue Development Cell Motility Angiogenesis Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Development Signaling Cell Communication Response To Stimulus Positive Regulation Of Cell Proliferation Signal Transduction Chemotaxis Wound Healing Organ Development Blood Coagulation Hemostasis System Development Cell-cell Adhesion Mediated By Integrin Single Organism Reproductive Process Response To Wounding Positive Regulation Of Kinase Activity Anatomical Structure Morphogenesis	Endoderm Development Regulation Of Endocytosis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Vesicle-mediated Transport Endodermal Cell Differentiation Endoderm Formation Regulation Of Cell Migration Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Phagocytosis Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Transport Negative Regulation Of Protein Metabolic Process Interaction With Host Positive Regulation Of Endocytosis Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Binding Formation Of Primary Germ Layer Cell Growth Negative Regulation Of Entry Of Bacterium Into Host Cell Defense Response To Fungus, Incompatible Interaction Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Cell Adhesion Cell-matrix Adhesion Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation Viral Life Cycle Vesicle-mediated Transport Regulation Of Entry Of Bacterium Into Host Cell Active Induction Of Host Immune Response By Virus Cell-substrate Adhesion MAPK Cascade Negative Regulation Of Locomotion Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Hyaluronan Biosynthetic Process Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Binding Tissue Development Signal Transduction By Phosphorylation Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Tolerance Induction To Self Antigen
Tagcloud ?		bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf	abcg2 agilent amplifying beta8 cepc cepcs connexin corneal cryosections dissociated epithelia genespring gx11 holoclone lentiviral limbal locked lpc mann micrornas oligo organotypic parabasal progenies rim scrambled transit v2 whitney
Tagcloud (Difference) ?		bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf	abcg2 agilent amplifying beta8 cepc cepcs connexin corneal cryosections dissociated epithelia genespring gx11 holoclone lentiviral limbal locked lpc mann micrornas oligo organotypic parabasal progenies rim scrambled transit v2 whitney
Tagcloud (Intersection) ?