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ITGAV and TGFB1
Number of citations of the paper that reports this interaction (PubMedID
11970960
)
54
Data Source:
HPRD
(in vivo)
ITGAV
TGFB1
Description
integrin subunit alpha V
transforming growth factor beta 1
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Lamellipodium Membrane
Filopodium Membrane
Microvillus Membrane
Ruffle Membrane
Integrin Alphav-beta1 Complex
Integrin Alphav-beta3 Complex
Integrin Alphav-beta5 Complex
Integrin Alphav-beta6 Complex
Integrin Alphav-beta8 Complex
Specific Granule Membrane
Alphav-beta3 Integrin-PKCalpha Complex
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Alphav-beta3 Integrin-HMGB1 Complex
Phagocytic Vesicle
Extracellular Exosome
Anchoring Junction
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Plasma Membrane
Microvillus
Cell Surface
Secretory Granule
Axon
Extracellular Matrix
Platelet Alpha Granule Lumen
Neuronal Cell Body
Blood Microparticle
Molecular Function
Virus Receptor Activity
Opsonin Binding
Fibronectin Binding
Protease Binding
Protein Kinase C Binding
Signaling Receptor Binding
Integrin Binding
Protein Binding
Coreceptor Activity
Fibroblast Growth Factor Binding
C-X3-C Chemokine Binding
Insulin-like Growth Factor I Binding
Signaling Receptor Activity
Neuregulin Binding
Metal Ion Binding
Transforming Growth Factor Beta Binding
Extracellular Matrix Binding
Extracellular Matrix Protein Binding
Type II Transforming Growth Factor Beta Receptor Binding
Cytokine Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Growth Factor Activity
Enzyme Binding
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Deubiquitinase Activator Activity
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Protein-containing Complex Binding
Biological Process
Angiogenesis
Blood Vessel Development
Vasculogenesis
Formation Of Primary Germ Layer
Cell Adhesion
Cell-matrix Adhesion
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Tissue Development
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Negative Regulation Of Low-density Lipoprotein Particle Clearance
Cell Migration
Positive Regulation Of Cell Migration
Cell-substrate Adhesion
Negative Regulation Of Lipid Transport
Cell Adhesion Mediated By Integrin
Positive Regulation Of Osteoblast Proliferation
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Apolipoprotein A-I-mediated Signaling Pathway
Apoptotic Cell Clearance
Positive Regulation Of Cell Adhesion
Symbiont Entry Into Host Cell
Negative Regulation Of Lipoprotein Metabolic Process
Regulation Of Phagocytosis
Negative Chemotaxis
Positive Regulation Of Small GTPase Mediated Signal Transduction
ERK1 And ERK2 Cascade
Calcium Ion Transmembrane Transport
Transforming Growth Factor Beta Production
Entry Into Host Cell By A Symbiont-containing Vacuole
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Cell-cell Adhesion
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Entry Of Bacterium Into Host Cell
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Vasculogenesis
Ureteric Bud Development
Response To Hypoxia
Morphogenesis Of A Branching Structure
Cell Activation
Epithelial To Mesenchymal Transition
Neural Tube Closure
Regulation Of Sodium Ion Transport
Sprouting Angiogenesis
Chondrocyte Differentiation
Columnar/cuboidal Epithelial Cell Maturation
Hematopoietic Progenitor Cell Differentiation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Tolerance Induction To Self Antigen
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Heart Valve Morphogenesis
Aortic Valve Morphogenesis
Protein Export From Nucleus
ATP Biosynthetic Process
Phosphate-containing Compound Metabolic Process
Intracellular Calcium Ion Homeostasis
Apoptotic Process
Inflammatory Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Negative Regulation Of Neuroblast Proliferation
Salivary Gland Morphogenesis
Endoderm Development
Heart Development
Female Pregnancy
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Germ Cell Migration
Response To Xenobiotic Stimulus
Response To Wounding
Response To Glucose
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Epithelial To Mesenchymal Transition
Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Fibroblast Migration
Negative Regulation Of Macrophage Cytokine Production
Oligodendrocyte Development
Positive Regulation Of Microglia Differentiation
Regulation Of Striated Muscle Tissue Development
Neural Tube Development
Hyaluronan Catabolic Process
T Cell Differentiation
Negative Regulation Of Ossification
Negative Regulation Of Cell Growth
Osteoclast Differentiation
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Mammary Gland Development
Animal Organ Regeneration
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Exit From Mitosis
Response To Estradiol
Response To Progesterone
Regulation Of Interleukin-23 Production
Negative Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Receptor Catabolic Process
Positive Regulation Of Superoxide Anion Generation
Mononuclear Cell Proliferation
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Collagen Biosynthetic Process
Response To Vitamin D
Response To Laminar Fluid Shear Stress
Response To Immobilization Stress
Myofibroblast Differentiation
T Cell Proliferation
T Cell Activation
Regulation Of Cell Population Proliferation
Negative Regulation Of T Cell Proliferation
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Protein Import Into Nucleus
Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of Odontogenesis
Myelination
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of Vascular Permeability
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Surfactant Homeostasis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulatory T Cell Differentiation
Cell-cell Junction Organization
Response To Ethanol
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Regulatory T Cell Differentiation
Negative Regulation Of Cell Differentiation
Positive Regulation Of Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Muscle Cell Cellular Homeostasis
Positive Regulation Of Fibroblast Proliferation
Lung Alveolus Development
Positive Regulation Of Isotype Switching To IgA Isotypes
Lymph Node Development
Digestive Tract Development
Negative Regulation Of Skeletal Muscle Tissue Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Inner Ear Development
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Secretion
Positive Regulation Of Inflammatory Response
Negative Regulation Of Phagocytosis
Defense Response To Fungus
Negative Regulation Of T Cell Activation
Positive Regulation Of Chemotaxis
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Regulation Of Cell Cycle
Positive Regulation Of Cell Division
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Ventricular Cardiac Muscle Tissue Morphogenesis
Phospholipid Homeostasis
Canonical Wnt Signaling Pathway
Regulation Of Blood Vessel Remodeling
Face Morphogenesis
Frontal Suture Morphogenesis
Positive Regulation Of SMAD Protein Signal Transduction
Bronchiole Development
Mammary Gland Branching Involved In Thelarche
Branch Elongation Involved In Mammary Gland Duct Branching
Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Cartilage Development
Retina Vasculature Development In Camera-type Eye
Connective Tissue Development
Langerhans Cell Differentiation
Negative Regulation Of Biomineral Tissue Development
Regulation Of Enamel Mineralization
Lens Fiber Cell Differentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Cholesterol
Cellular Response To Mechanical Stimulus
Cellular Response To Glucose Stimulus
Cellular Response To Growth Factor Stimulus
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Hypoxia
Cellular Response To Ionizing Radiation
Cellular Response To Dexamethasone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Mononuclear Cell Migration
Odontoblast Differentiation
Stem Cell Proliferation
Extracellular Matrix Assembly
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Liver Regeneration
Cellular Response To Virus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Negative Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Extracellular Matrix Assembly
Response To Salt
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Regulation Of MiRNA Transcription
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Vasculature Development
Positive Regulation Of Receptor Signaling Pathway Via STAT
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cellular Response To Acetaldehyde
Cellular Response To Insulin-like Growth Factor Stimulus
Embryonic Liver Development
Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Primary MiRNA Processing
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Integrin cell surface interactions
TGF-beta receptor signaling activates SMADs
Laminin interactions
Syndecan interactions
Syndecan interactions
ECM proteoglycans
VEGFA-VEGFR2 Pathway
Signal transduction by L1
Neutrophil degranulation
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Platelet degranulation
Influenza Virus Induced Apoptosis
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Syndecan interactions
ECM proteoglycans
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Transcriptional regulation of white adipocyte differentiation
UCH proteinases
Interleukin-4 and Interleukin-13 signaling
RUNX3 regulates CDKN1A transcription
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
TGFBR3 regulates TGF-beta signaling
Drugs
Antithymocyte immunoglobulin (rabbit)
Levothyroxine
PLN-74809
Hyaluronidase (ovine)
Terazosin
Hyaluronidase (human recombinant)
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Hyaluronidase
Diseases
Graft-versus-host disease
Allograft rejection
Camurati-Engelmann disease; Progressive diaphyseal dysplasia
GWAS
Asthma (
32296059
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Left-handedness (
32989287
)
Lung function (FEV1/FVC) (
30804560
)
Microalbuminuria (
26631737
)
Urinary albumin-to-creatinine ratio (
26631737
)
Urinary albumin-to-creatinine ratio in non-diabetics (
26631737
)
Alanine aminotransferase levels (
34315874
)
Aspartate aminotransferase levels (
34315874
)
Colorectal cancer (
24836286
27145994
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
28714974
29212778
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Hematuria (
30476138
)
Hematuria (mild) (
30476138
)
Hematuria (moderate to severe) (
30476138
)
Platelet count (
32888494
)
Preterm birth (maternal effect) (
28877031
)
Pulse pressure (
30578418
)
Type 2 diabetes (
31049640
)
Interacting Genes
38 interacting genes:
ADAM9
ANGPTL3
AUP1
AZGP1
CALR
CCN1
CCN3
CD47
COL11A1
COL18A1
COL6A1
EDIL3
F2R
ICAM4
ITGB1
ITGB3
ITGB5
ITGB6
ITGB8
L1CAM
LGALS3BP
MAPK3
MMP14
MMP2
NID1
P2RY2
PAK4
PDGFRA
PLA2G2A
PLP1
PTK2
PXN
SPP1
TGFB1
TGM2
THY1
UBC
VTN
99 interacting genes:
ACVRL1
ADAMTSL4
AGR3
ANGPTL4
APC
APP
AURKA
AXIN2
BCAS3
BCL10
BGN
BLID
BMP2
BMP3
BMPR1A
BUB1
CATSPER1
CCDC33
CCL3
CCL5
CCN2
CDKN2A
CFTR
COL2A1
CST6
CYSRT1
DAXX
DCN
DIRAS3
DLC1
DPT
EGFR
EIF3I
ENG
ERBB2
FBXW7
FCHO1
FCN1
FKBP1A
FMOD
FNTA
GREB1
HOXA1
HOXC6
ITGAV
ITGB6
ITGB8
KLK5
KLK7
KLK9
KRTAP1-1
KRTAP1-3
KRTAP10-8
KRTAP4-11
LAMTOR5
LCE1A
LCE1C
LCE1D
LCE1F
LCE2B
LCE2C
LCE3A
LCE3B
LCE3D
LCE5A
LPXN
LTBP1
LTBP3
LTBP4
MCC
MEOX2
MLH3
MMP2
MTA3
NSD3
P4HB
PDGFRL
PDLIM2
POU4F2
PRSS50
PSMC3IP
PZP
RAPGEF3
SCGB3A1
SDC2
SNAI1
SPARC
ST14
TGFB2
TGFBR1
TGFBR2
TGFBR3
THBS1
THRSP
TLR2
UBC
VASN
VTN
YWHAE
Entrez ID
3685
7040
HPRD ID
01903
01821
Ensembl ID
ENSG00000138448
ENSG00000105329
Uniprot IDs
L7RXH0
P06756
A0A499FJK2
P01137
PDB IDs
1JV2
1L5G
1M1X
1U8C
3IJE
4G1E
4G1M
4MMX
4MMY
4MMZ
4O02
4UM8
4UM9
5FFG
5FFO
5NEM
5NER
5NET
5NEU
6AVQ
6AVR
6AVU
6DJP
6MK0
6MSL
6MSU
6NAJ
6OM1
6OM2
6UJA
6UJB
6UJC
7Y1T
8IJ5
8TCF
8TCG
8VS6
8VSD
8W30
8XEI
8XEK
8XEL
8XEN
8XER
8XEZ
8XF6
8XFG
8XFO
9CZ7
9CZA
9CZD
9CZF
9IND
1KLA
1KLC
1KLD
3KFD
4KV5
5FFO
5VQP
6OM2
6P7J
7Y1R
7Y1T
8UDZ
8VSC
8VSD
9FDY
9FKP
Enriched GO Terms of Interacting Partners
?
Integrin Binding
Cell Adhesion
Integrin-mediated Signaling Pathway
Cell Adhesion Mediated By Integrin
Focal Adhesion
Extracellular Matrix
Positive Regulation Of Cell Migration
Cell-matrix Adhesion
Positive Regulation Of Cell Motility
Cell-substrate Adhesion
Positive Regulation Of Locomotion
Angiogenesis
Cell-cell Adhesion
Cell Migration
Regulation Of Cell Adhesion
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Cell Migration
Regulation Of Cell Motility
Cell Motility
Regulation Of Locomotion
Cell Surface
Enzyme-linked Receptor Protein Signaling Pathway
Extracellular Matrix Binding
Transforming Growth Factor Beta Receptor Signaling Pathway
Extracellular Matrix Organization
Extracellular Structure Organization
Endodermal Cell Differentiation
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Extracellular Region
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Multicellular Organismal Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Mononuclear Cell Migration
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Leukocyte Migration
Regulation Of Leukocyte Migration
Extracellular Exosome
Positive Regulation Of Mononuclear Cell Migration
Positive Regulation Of Multicellular Organismal Process
Integrin Complex
Developmental Process
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Adhesion
Response To Mechanical Stimulus
Positive Regulation Of Cell-substrate Adhesion
Cellular Developmental Process
Cell Differentiation
Extracellular Space
Positive Regulation Of Fibroblast Migration
Transforming Growth Factor Beta Binding
Tissue Development
Epidermis Development
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Formation Involved In Morphogenesis
Developmental Process
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Extracellular Matrix
Cell Surface Receptor Signaling Pathway
Keratinization
Endocardial Cushion Morphogenesis
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Locomotion
Regulation Of Cell Motility
Positive Regulation Of SMAD Protein Signal Transduction
Extracellular Space
Regulation Of Cell Migration
Cardiac Epithelial To Mesenchymal Transition
Anatomical Structure Morphogenesis
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Extracellular Matrix Organization
Extracellular Structure Organization
Activin Binding
Positive Regulation Of Cell Migration
Glycosaminoglycan Binding
Regulation Of Multicellular Organismal Process
Regulation Of Epithelial Cell Proliferation
Response To Growth Factor
Cell Surface
Positive Regulation Of Cell Motility
Regulation Of SMAD Protein Signal Transduction
Animal Organ Morphogenesis
Positive Regulation Of Locomotion
Extracellular Region
Regulation Of Programmed Cell Death
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Roof Of Mouth Development
Extracellular Matrix Binding
Regulation Of Apoptotic Process
Regulation Of Signal Transduction
Epithelial To Mesenchymal Transition
Heart Morphogenesis
Cardiac Muscle Tissue Morphogenesis
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Tagcloud (Intersection)
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