ITGAV and CD47

Number of citations of the paper that reports this interaction (PMID 10545994)
35

Data Source:
HPRD (in vivo, in vitro)

		ITGAV	CD47
Gene Name		integrin, alpha V	CD47 molecule
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta8 Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Phagocytic Vesicle Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Voltage-gated Calcium Channel Activity Protein Binding Insulin-like Growth Factor I Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding	Protein Binding Thrombospondin Receptor Activity
	Biological Process	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Cell Growth Cell Migration Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Apoptotic Cell Clearance Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Cell Adhesion Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Leukocyte Migration Negative Chemotaxis Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Cell Clearance Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Opsonization Positive Regulation Of Cell Proliferation Response To Bacterium Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Leukocyte Migration
Pathways		Signal transduction by L1 Axon guidance Elastic fibre formation L1CAM interactions Non-integrin membrane-ECM interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Laminin interactions Signaling by VEGF ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System	Integrin cell surface interactions Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CD47 CYR61 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM MMP14 MMP2 NID1 NOV P2RY2 PAK4 PDGFRA PLP1 PTK2 SPP1 TGFB1 THY1	12 interactors: BNIP3 EPB42 FAS GNAI1 ITGAV P2RY2 PTK2 RHAG SIRPA SYNE4 THBS1 UBQLN1
Entrez ID		3685	961
HPRD ID		01903	03017
Ensembl ID		ENSG00000138448	ENSG00000196776
Uniprot IDs		B7ZLX0 P06756	Q08722
PDB IDs		1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M	2JJS 2JJT 2VSC 4KJY
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-matrix Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Locomotion Regulation Of Cell-substrate Adhesion Cardiovascular System Development Blood Vessel Development Response To External Stimulus Vasculature Development Single Organismal Cell-cell Adhesion Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Developmental Process Blood Vessel Morphogenesis Cell Migration Tissue Development Cell Motility Angiogenesis Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Development Signaling Cell Communication Response To Stimulus Positive Regulation Of Cell Proliferation Signal Transduction Chemotaxis Wound Healing Organ Development Blood Coagulation Hemostasis System Development Cell-cell Adhesion Mediated By Integrin Single Organism Reproductive Process Response To Wounding Positive Regulation Of Kinase Activity Anatomical Structure Morphogenesis	Blood Coagulation Hemostasis Immune System Process Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cellular Response To Oxygen Levels Regulation Of Apoptotic Process Cellular Response To Inorganic Substance Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Lipid Transport Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Death Death Platelet Activation Response To Hyperoxia Apoptotic Cell Clearance Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Regulation Of Cellular Component Organization Erythrocyte Development Homeostasis Of Number Of Cells Peptide Cross-linking Spleen Development Regulation Of Focal Adhesion Assembly Phagocytosis Cell Activation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Apoptotic Process Response To Hypoxia Regulation Of Cell Junction Assembly Cell Differentiation Neuron Death Angiogenesis Response To Metal Ion Positive Regulation Of Cell Migration Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cell Motility Cell Migration Apoptotic Signaling Pathway
Tagcloud ?		bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf	1p34 ancestral asymmetry bilayer connecting deduced duffy ee glycophorin glycoproteins glycosylated helices hydrophilic leaflets loops lw multimeric occasions phospholipid primates reside rh rh50 rhce rhd rhnull specificities suffer topology
Tagcloud (Difference) ?		bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf	1p34 ancestral asymmetry bilayer connecting deduced duffy ee glycophorin glycoproteins glycosylated helices hydrophilic leaflets loops lw multimeric occasions phospholipid primates reside rh rh50 rhce rhd rhnull specificities suffer topology
Tagcloud (Intersection) ?