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ITGAL and PTPRC
Number of citations of the paper that reports this interaction (PubMedID
15946252
)
45
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
ITGAL
PTPRC
Description
integrin subunit alpha L
protein tyrosine phosphatase receptor type C
Image
GO Annotations
Cellular Component
Plasma Membrane
Integrin Complex
Cell Surface
Membrane
Secretory Granule Membrane
Integrin AlphaL-beta2 Complex
Specific Granule Membrane
Extracellular Exosome
Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Secretory Granule Membrane
Bleb
Membrane Raft
Synapse
Extracellular Exosome
Cell Periphery
Side Of Membrane
Membrane Microdomain
Molecular Function
Protein Binding
ICAM-3 Receptor Activity
Signaling Receptor Activity
Protein-containing Complex Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Hydrolase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Inhibitor Activity
Ankyrin Binding
Spectrin Binding
Heparan Sulfate Proteoglycan Binding
Biological Process
T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Phagocytosis
Inflammatory Response
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Integrin-mediated Signaling Pathway
Memory T Cell Extravasation
T Cell Activation
Receptor Clustering
Cell-cell Adhesion
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Natural Killer Cell Differentiation
Negative Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of T Cell Mediated Cytotoxicity
Negative Regulation Of Cytokine-mediated Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Positive Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Mediated Immunity
Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Negative Regulation Of Protein Kinase Activity
Protein Dephosphorylation
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Leukocyte Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Response To Gamma Radiation
Regulation Of Gene Expression
Dephosphorylation
B Cell Differentiation
T Cell Differentiation
Positive Regulation Of B Cell Proliferation
Regulation Of Interleukin-8 Production
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Tumor Necrosis Factor Production
Heterotypic Cell-cell Adhesion
T Cell Proliferation
B Cell Proliferation
Positive Regulation Of T Cell Proliferation
T Cell Activation
Gamma-delta T Cell Differentiation
Positive Regulation Of MAPK Cascade
Cell Cycle Phase Transition
Plasma Membrane Raft Distribution
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Alpha-beta T Cell Proliferation
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
Bone Marrow Development
Stem Cell Development
Regulation Of Phagocytosis
Positive Regulation Of Phagocytosis
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of Antigen Receptor-mediated Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Defense Response To Virus
Regulation Of Cell Cycle
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Microglial Cell Activation
Response To Aldosterone
DN2 Thymocyte Differentiation
Positive Regulation Of Hematopoietic Stem Cell Migration
Positive Regulation Of Stem Cell Proliferation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Neutrophil degranulation
RUNX3 Regulates Immune Response and Cell Migration
Phosphorylation of CD3 and TCR zeta chains
Other semaphorin interactions
Neutrophil degranulation
Drugs
Efalizumab
Antithymocyte immunoglobulin (rabbit)
Lovastatin
Simvastatin
Rosuvastatin
1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine
LFA703
(S)-2-((S)-3-isobutyl-2,5-dioxo-4-quinolin-3-ylmethyl-[1,4]diazepan-1yl)-N-methyl-3-naphtalen-2-yl-propionamide
7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile
3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline
Pitavastatin
Lifitegrast
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
27863252
32888494
)
Smooth-surface caries (
24556642
)
Ulcerative colitis (
23128233
28067908
)
White blood cell count (
27863252
32888494
)
Apolipoprotein B levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Asthma (
31959851
34103634
32296059
31619474
30929738
)
Asthma (adult onset) (
30929738
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
28067908
26192919
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Inflammatory bowel disease (
26192919
)
LDL cholesterol levels (
32203549
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
20139978
29403010
28017375
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
29403010
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Plateletcrit (
32888494
)
Red blood cell count (
29403010
32888494
)
Refractive error (
32231278
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
33272962
)
Type 1 diabetes (
34012112
)
Ulcerative colitis (
24837172
)
Vitiligo (
27723757
)
White blood cell count (
32888494
)
Interacting Genes
7 interacting genes:
F11R
ICAM1
ICAM3
ICAM5
PTPRC
RANBP9
SHARPIN
45 interacting genes:
ANP32A
CD1D
CD2
CD22
CD247
CD28
CD4
CD8A
CSNK2A1
CSNK2A2
CXCR4
DPP4
EZR
FCGR3A
FYN
GANAB
GRB2
IFNAR1
INSR
IRS1
ITGAL
JAK1
JAK2
JAK3
LCK
LCP2
LGALS1
LSM1
LYN
MAPK1
MBL2
PAEP
PPFIA1
PPFIBP2
PRKCSH
PTPN6
PTPRCAP
RASA1
RNF11
SEMA4D
SKAP1
SRC
TYK2
UHRF2
ZAP70
Entrez ID
3683
5788
HPRD ID
01079
01050
Ensembl ID
ENSG00000005844
ENSG00000081237
Uniprot IDs
B2RAL6
P20701
M9MML4
P08575
PDB IDs
1CQP
1DGQ
1LFA
1MJN
1MQ8
1MQ9
1MQA
1RD4
1T0P
1XDD
1XDG
1XUO
1ZON
1ZOO
1ZOP
2ICA
2K8O
2M3E
2O7N
3BN3
3BQM
3BQN
3E2M
3EOA
3EOB
3F74
3F78
3HI6
3M6F
3TCX
4IXD
5E6R
5E6S
5E6U
6BXB
6BXF
6BXJ
6CKB
7KC3
7KC5
7KC6
1YGR
1YGU
5FMV
5FN6
5FN7
8VSE
Enriched GO Terms of Interacting Partners
?
Integrin Binding
Cell-cell Adhesion
T Cell Extravasation
Leukocyte Cell-cell Adhesion
Cell Adhesion
Cellular Extravasation
Establishment Of Endothelial Barrier
T Cell Migration
Endothelial Cell Development
Regulation Of ERK1 And ERK2 Cascade
Lymphocyte Migration
Regulation Of Intracellular Signal Transduction
Negative Regulation Of ERK1 And ERK2 Cascade
Plasma Membrane Raft Distribution
Virus Receptor Activity
Positive Regulation Of Intracellular Signal Transduction
Mononuclear Cell Migration
Regulation Of Leukocyte Mediated Cytotoxicity
Phagocytosis
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Hematopoietic Stem Cell Migration
Memory T Cell Extravasation
Symbiont Entry Into Host Cell
Epithelial Cell Development
Membrane Microdomain
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Membrane To Membrane Docking
T Cell Antigen Processing And Presentation
Regulation Of MAPK Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Biological Process Involved In Interaction With Host
Plasma Membrane
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Negative Regulation Of MAPK Cascade
DN2 Thymocyte Differentiation
Negative Regulation Of Inflammatory Response
Regulation Of Cytokine-mediated Signaling Pathway
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Positive Regulation Of Establishment Of Endothelial Barrier
Protein Localization To Bicellular Tight Junction
LUBAC Complex
Apoptotic Nuclear Changes
Regulation Of CD40 Signaling Pathway
Membrane Raft
T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Positive Regulation Of Cell Communication
Regulation Of Signal Transduction
Receptor-mediated Virion Attachment To Host Cell
Leukocyte Activation
Cell Surface Receptor Signaling Pathway
Lymphocyte Activation
Cell Activation
Regulation Of Immune Response
Positive Regulation Of Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
T Cell Costimulation
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Positive Regulation Of Immune System Process
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Immune Response
Immune System Process
Regulation Of Cell-cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of Cell Activation
Regulation Of Immune System Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Immune Response-regulating Signaling Pathway
Positive Regulation Of Cell Adhesion
Immune Response-activating Signaling Pathway
Immune Response
Activation Of Immune Response
T Cell Activation
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
T Cell Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Peptidyl-tyrosine Phosphorylation
Protein Tyrosine Kinase Activity
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Protein Kinase Activity
Protein Phosphorylation
Regulation Of Leukocyte Proliferation
Phosphorylation
Immune Effector Process
Signaling Receptor Binding
Lymphocyte Differentiation
Regulation Of Mononuclear Cell Proliferation
Fc Receptor Signaling Pathway
Mononuclear Cell Differentiation
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Tagcloud (Intersection)
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