ITGAL and ICAM1

Number of citations of the paper that reports this interaction (PMID 12526797)
137

Data Source:
BioGRID (x-ray crystallography, pull down)

		ITGAL	ICAM1
Gene Name		integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	intercellular adhesion molecule 1
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell-cell Junction Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Extracellular Vesicular Exosome	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding	Virus Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding
	Biological Process	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Movement Of Cell Or Subcellular Component Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Blood Coagulation Extracellular Matrix Organization Positive Regulation Of T Cell Proliferation Receptor Clustering Regulation Of Immune Response Activated T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Leukocyte Migration	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Virus Response To Ionizing Radiation Response To Sulfur Dioxide Response To Organic Cyclic Compound Cytokine-mediated Signaling Pathway Membrane To Membrane Docking Regulation Of Cell Adhesion Extracellular Matrix Organization Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Positive Regulation Of Rho GTPase Activity Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Drug Response To Amino Acid Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs		Efalizumab Antithymocyte globulin Lovastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline	Natalizumab Hyaluronan
Diseases
GWAS		Ulcerative colitis ( 23128233)	Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Soluble ICAM-1 ( 21533024 18604267)
Protein-Protein Interactions		7 interactors: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN	12 interactors: EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 MSN SLC3A2 SPN
Entrez ID		3683	3383
HPRD ID		01079	00996
Ensembl ID		ENSG00000005844	ENSG00000090339
Uniprot IDs		B2RAL6 P20701	B4DQW5 E7ESS4 P05362
PDB IDs		1CQP 1DGQ 1IJ4 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX	1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Establishment Of Endothelial Barrier Endothelial Cell Development Extracellular Matrix Organization Extracellular Structure Organization Endothelial Cell Differentiation Response To Radiation Locomotion Response To Sulfur Dioxide Endothelium Development Regulation Of Cytokine-mediated Signaling Pathway Epithelial Cell Differentiation Regulation Of Leukocyte Mediated Cytotoxicity Movement Of Cell Or Subcellular Component T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Response To Ionizing Radiation Tissue Development Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Regulation Of Intracellular Signal Transduction Cell Development Cell Differentiation Positive Regulation Of Intracellular Signal Transduction Cell Migration T Cell Antigen Processing And Presentation Receptor-mediated Virion Attachment To Host Cell Membrane To Membrane Docking Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune Response Epithelial Cell Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Extravasation Negative Regulation Of T Cell Mediated Cytotoxicity Cell Motility Leukocyte Migration Establishment Of Sertoli Cell Barrier Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Virion Attachment To Host Cell Response To Virus Positive Regulation Of Gamma-delta T Cell Differentiation Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Isotype Switching To IgG Isotypes Adhesion Of Symbiont To Host	Single Organismal Cell-cell Adhesion Leukocyte Migration Leukocyte Cell-cell Adhesion Cell Adhesion Locomotion Blood Coagulation Hemostasis Cell Migration Cell Motility Immune System Process Movement Of Cell Or Subcellular Component Activated T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Homotypic Cell-cell Adhesion Cell Activation Response To Wounding Immune Response Regulation Of Immune System Process Interleukin-2-mediated Signaling Pathway Regulation Of Immune Response Membrane To Membrane Docking T Cell Proliferation Positive Regulation Of Cell-cell Adhesion Chemotaxis T Cell Aggregation T Cell Activation Lymphocyte Aggregation Positive Regulation Of T Cell Proliferation Leukocyte Aggregation Response To Interleukin-2 Leukocyte Migration Involved In Inflammatory Response Cell Proliferation Lymphocyte Proliferation Defense Response Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Leukocyte Proliferation Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Extracellular Structure Organization Positive Regulation Of Cell Adhesion Lymphocyte Activation Inflammatory Response Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Response To Stress Cellular Extravasation
Tagcloud ?		a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgb2 loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly	baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3
Tagcloud (Difference) ?		a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgb2 loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly	baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3
Tagcloud (Intersection) ?