ITGAL and F11R

Number of citations of the paper that reports this interaction (PMID 11812992)
89

Data Source:
HPRD (in vivo, two hybrid)

		ITGAL	F11R
Gene Name		integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	F11 receptor
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell-cell Junction Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Extracellular Vesicular Exosome	Plasma Membrane Cell-cell Junction Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Cell Junction Cytoplasmic Vesicle Slit Diaphragm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding	Protein Binding PDZ Domain Binding
	Biological Process	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Movement Of Cell Or Subcellular Component Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Blood Coagulation Extracellular Matrix Organization Positive Regulation Of T Cell Proliferation Receptor Clustering Regulation Of Immune Response Activated T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Leukocyte Migration	Inflammatory Response Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Response To Radiation Viral Process Extracellular Matrix Organization Actomyosin Structure Organization Positive Regulation Of Rap GTPase Activity Negative Regulation Of Rho GTPase Activity Cell Junction Assembly Cell-cell Junction Organization Positive Regulation Of Blood Pressure Intestinal Absorption Leukocyte Migration Tight Junction Assembly Establishment Of Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Regulation Of Actin Cytoskeleton Reorganization
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System	Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Cell surface interactions at the vascular wall Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Integrin cell surface interactions SMAD4 MH2 Domain Mutants in Cancer
Drugs		Efalizumab Antithymocyte globulin Lovastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline
Diseases
GWAS		Ulcerative colitis ( 23128233)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN	16 interactors: ASIP BDNF CASK CGN CSNK2A1 F2RL2 ITGAL MLLT4 MPDZ PARD3 PEX19 PICK1 PRKCA PTPRB SGTA TJP1
Entrez ID		3683	50848
HPRD ID		01079	12038
Ensembl ID		ENSG00000005844	ENSG00000158769
Uniprot IDs		B2RAL6 P20701	B7Z941 Q6FIB4 Q9Y624
PDB IDs		1CQP 1DGQ 1IJ4 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX	1NBQ 3EOY 3TSZ
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Establishment Of Endothelial Barrier Endothelial Cell Development Extracellular Matrix Organization Extracellular Structure Organization Endothelial Cell Differentiation Response To Radiation Locomotion Response To Sulfur Dioxide Endothelium Development Regulation Of Cytokine-mediated Signaling Pathway Epithelial Cell Differentiation Regulation Of Leukocyte Mediated Cytotoxicity Movement Of Cell Or Subcellular Component T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Response To Ionizing Radiation Tissue Development Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Regulation Of Intracellular Signal Transduction Cell Development Cell Differentiation Positive Regulation Of Intracellular Signal Transduction Cell Migration T Cell Antigen Processing And Presentation Receptor-mediated Virion Attachment To Host Cell Membrane To Membrane Docking Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune Response Epithelial Cell Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Extravasation Negative Regulation Of T Cell Mediated Cytotoxicity Cell Motility Leukocyte Migration Establishment Of Sertoli Cell Barrier Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Virion Attachment To Host Cell Response To Virus Positive Regulation Of Gamma-delta T Cell Differentiation Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Isotype Switching To IgG Isotypes Adhesion Of Symbiont To Host	Cell Junction Assembly Cell-cell Junction Organization Cell-cell Junction Assembly Establishment Of Endothelial Intestinal Barrier Signal Transduction Epithelial Cell Development Membrane Organization Cell-cell Signaling Signaling Cell Communication Anatomical Structure Development Protein Localization To Membrane Cell Development Cellular Response To Stimulus Developmental Process Establishment Of Endothelial Barrier Epithelial Cell Differentiation Cell Surface Receptor Signaling Pathway Endothelial Cell Development Tight Junction Assembly Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Epithelial Cell Morphogenesis Epithelium Development Anatomical Structure Morphogenesis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Wound Healing Response To Growth Factor Receptor Clustering Tissue Development G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Involved In Cell-cell Junction Organization Response To Anesthetic Negative Regulation Of Lipid Binding Positive Regulation Of Dense Core Granule Biogenesis Response To Fluoxetine Response To L-glutamate Cell Differentiation Cell Adhesion Chaperone-mediated Protein Folding Negative Regulation Of Synaptic Transmission Cellular Response To Organic Substance Response To Wounding Response To Stimulus Locomotion Apical Junction Assembly Cell Morphogenesis Involved In Differentiation Endothelial Cell Differentiation Cellular Response To Carbohydrate Stimulus Multicellular Organismal Development
Tagcloud ?		a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgb2 loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Difference) ?		a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgb2 loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Intersection) ?