ITGAL and RANBP9

Number of citations of the paper that reports this interaction (PubMedID 14722085)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ITGAL	RANBP9
Description		integrin subunit alpha L	RAN binding protein 9
Image
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane Secretory Granule Membrane Integrin AlphaL-beta2 Complex Specific Granule Membrane Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Membrane Nuclear Body
	Molecular Function	Protein Binding ICAM-3 Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding	Protein Binding Enzyme Binding Small GTPase Binding
	Biological Process	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phagocytosis Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Memory T Cell Extravasation T Cell Activation Receptor Clustering Cell-cell Adhesion	Cytoskeleton Organization Microtubule Nucleation Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Neutrophil degranulation RUNX3 Regulates Immune Response and Cell Migration	L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling Regulation of pyruvate metabolism
Drugs		Efalizumab Antithymocyte immunoglobulin (rabbit) Lovastatin Simvastatin Rosuvastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-isobutyl-2,5-dioxo-4-quinolin-3-ylmethyl-[1,4]diazepan-1yl)-N-methyl-3-naphtalen-2-yl-propionamide 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline Pitavastatin Lifitegrast
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Smooth-surface caries ( 24556642) Ulcerative colitis ( 23128233 28067908) White blood cell count ( 27863252 32888494)	Breast cancer ( 23535729 29059683)
Interacting Genes		7 interacting genes: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN	67 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 BTG3 CACNA1G CALB1 CBR1 CBR3 CBS CCND1 CDK11B CDKN1A CFAP298 CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 GATD3 GID8 GRIK1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LCOR LMNA MAPK6 MET MORC3 MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOD1 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 ZBED1
Entrez ID		3683	10048
HPRD ID		01079	04835
Ensembl ID		ENSG00000005844	ENSG00000010017
Uniprot IDs		B2RAL6 P20701	Q96S59
PDB IDs		1CQP 1DGQ 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2M3E 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX 4IXD 5E6R 5E6S 5E6U 6BXB 6BXF 6BXJ 6CKB 7KC3 7KC5 7KC6	5JI7 5JI9 5JIU 7NSC
Enriched GO Terms of Interacting Partners?		Integrin Binding Cell-cell Adhesion T Cell Extravasation Leukocyte Cell-cell Adhesion Cell Adhesion Cellular Extravasation Establishment Of Endothelial Barrier T Cell Migration Endothelial Cell Development Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Raft Distribution Virus Receptor Activity Positive Regulation Of Intracellular Signal Transduction Mononuclear Cell Migration Regulation Of Leukocyte Mediated Cytotoxicity Phagocytosis Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Memory T Cell Extravasation Symbiont Entry Into Host Cell Epithelial Cell Development Membrane Microdomain Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Membrane To Membrane Docking T Cell Antigen Processing And Presentation Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Biological Process Involved In Interaction With Host Plasma Membrane Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of MAPK Cascade DN2 Thymocyte Differentiation Negative Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction LUBAC Complex Apoptotic Nuclear Changes Regulation Of CD40 Signaling Pathway Membrane Raft T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Cell Communication Regulation Of Signal Transduction Receptor-mediated Virion Attachment To Host Cell	Developmental Process Cellular Developmental Process Animal Organ Development Regulation Of Programmed Cell Death Nucleoplasm Protein-containing Complex Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Nuclear Receptor Activity Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Condensate Scaffold Activity Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Chromatin Binding Regulation Of Growth Apoptotic Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?