ITGAL

Description		integrin subunit alpha L
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GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane Secretory Granule Membrane Integrin AlphaL-beta2 Complex Specific Granule Membrane Extracellular Exosome
	Molecular Function	Protein Binding ICAM-3 Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phagocytosis Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Memory T Cell Extravasation T Cell Activation Receptor Clustering Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Neutrophil degranulation RUNX3 Regulates Immune Response and Cell Migration
Drugs		Efalizumab Antithymocyte immunoglobulin (rabbit) Lovastatin Simvastatin Rosuvastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-isobutyl-2,5-dioxo-4-quinolin-3-ylmethyl-[1,4]diazepan-1yl)-N-methyl-3-naphtalen-2-yl-propionamide 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline Pitavastatin Lifitegrast
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Smooth-surface caries ( 24556642) Ulcerative colitis ( 23128233 28067908) White blood cell count ( 27863252 32888494)
Interacting Genes		7 interacting genes: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN
Entrez ID		3683
HPRD ID		01079
Ensembl ID		ENSG00000005844
Uniprot IDs		B2RAL6 P20701
PDB IDs		1CQP 1DGQ 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2M3E 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX 4IXD 5E6R 5E6S 5E6U 6BXB 6BXF 6BXJ 6CKB 7KC3 7KC5 7KC6
Enriched GO Terms of Interacting Partners?		Integrin Binding Cell-cell Adhesion T Cell Extravasation Leukocyte Cell-cell Adhesion Cell Adhesion Cellular Extravasation Establishment Of Endothelial Barrier T Cell Migration Endothelial Cell Development Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Raft Distribution Virus Receptor Activity Positive Regulation Of Intracellular Signal Transduction Mononuclear Cell Migration Regulation Of Leukocyte Mediated Cytotoxicity Phagocytosis Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Memory T Cell Extravasation Symbiont Entry Into Host Cell Epithelial Cell Development Membrane Microdomain Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Membrane To Membrane Docking T Cell Antigen Processing And Presentation Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Biological Process Involved In Interaction With Host Plasma Membrane Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of MAPK Cascade DN2 Thymocyte Differentiation Negative Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction LUBAC Complex Apoptotic Nuclear Changes Regulation Of CD40 Signaling Pathway Membrane Raft T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Cell Communication Regulation Of Signal Transduction Receptor-mediated Virion Attachment To Host Cell
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