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ITGAL
Gene Name
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Image
Gene Ontology Annotations
Cellular Component
Immunological Synapse
Plasma Membrane
Cell-cell Junction
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Integrin AlphaL-beta2 Complex
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
ICAM-3 Receptor Activity
Protein Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Cell Adhesion Molecule Binding
Biological Process
T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Movement Of Cell Or Subcellular Component
Inflammatory Response
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Integrin-mediated Signaling Pathway
Blood Coagulation
Extracellular Matrix Organization
Positive Regulation Of T Cell Proliferation
Receptor Clustering
Regulation Of Immune Response
Activated T Cell Proliferation
Positive Regulation Of Calcium-mediated Signaling
Leukocyte Migration
Pathways
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Adaptive Immune System
Drugs
Efalizumab
Antithymocyte globulin
Lovastatin
1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine
LFA703
(S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE
7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile
3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline
Diseases
GWAS
Ulcerative colitis (
23128233
)
Protein-protein Interactions
7 interactors:
F11R
ICAM1
ICAM3
ICAM5
PTPRC
RANBP9
SHARPIN
Entrez ID
3683
HPRD ID
01079
Ensembl ID
ENSG00000005844
Uniprot IDs
B2RAL6
P20701
PDB IDs
1CQP
1DGQ
1IJ4
1LFA
1MJN
1MQ8
1MQ9
1MQA
1RD4
1T0P
1XDD
1XDG
1XUO
1ZON
1ZOO
1ZOP
2ICA
2K8O
2O7N
3BN3
3BQM
3BQN
3E2M
3EOA
3EOB
3F74
3F78
3HI6
3M6F
3TCX
Enriched GO Terms of Interacting Partners
?
Cell Adhesion
Single Organismal Cell-cell Adhesion
Establishment Of Endothelial Barrier
Endothelial Cell Development
Extracellular Matrix Organization
Extracellular Structure Organization
Endothelial Cell Differentiation
Response To Radiation
Locomotion
Response To Sulfur Dioxide
Endothelium Development
Regulation Of Cytokine-mediated Signaling Pathway
Epithelial Cell Differentiation
Regulation Of Leukocyte Mediated Cytotoxicity
Movement Of Cell Or Subcellular Component
T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Immunoglobulin Biosynthetic Process
Positive Regulation Of Hematopoietic Stem Cell Migration
Response To Ionizing Radiation
Tissue Development
Regulation Of CD40 Signaling Pathway
Protein Linear Polyubiquitination
Regulation Of Intracellular Signal Transduction
Cell Development
Cell Differentiation
Positive Regulation Of Intracellular Signal Transduction
Cell Migration
T Cell Antigen Processing And Presentation
Receptor-mediated Virion Attachment To Host Cell
Membrane To Membrane Docking
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Immune Response
Epithelial Cell Development
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cellular Extravasation
Negative Regulation Of T Cell Mediated Cytotoxicity
Cell Motility
Leukocyte Migration
Establishment Of Sertoli Cell Barrier
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Establishment Of Endothelial Intestinal Barrier
Positive Regulation Of Isotype Switching To IgG Isotypes
Bone Marrow Development
Virion Attachment To Host Cell
Response To Virus
Positive Regulation Of Gamma-delta T Cell Differentiation
Acute Inflammatory Response To Antigenic Stimulus
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Regulation Of Isotype Switching To IgG Isotypes
Adhesion Of Symbiont To Host
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a2
caucasians
cd8a
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icam
il1b
il2
itgb2
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