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ITGAL and SHARPIN
Number of citations of the paper that reports this interaction (PubMedID
26600301
)
32
Data Source:
BioGRID
(pull down, unspecified method, far western blotting, affinity chromatography technology)
ITGAL
SHARPIN
Description
integrin subunit alpha L
SHANK associated RH domain interactor
Image
GO Annotations
Cellular Component
Plasma Membrane
Integrin Complex
Cell Surface
Membrane
Secretory Granule Membrane
Integrin AlphaL-beta2 Complex
Specific Granule Membrane
Extracellular Exosome
Cytoplasm
Cytosol
Synapse
LUBAC Complex
Molecular Function
Protein Binding
ICAM-3 Receptor Activity
Signaling Receptor Activity
Protein-containing Complex Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Protein-macromolecule Adaptor Activity
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Binding
Metal Ion Binding
Biological Process
T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Phagocytosis
Inflammatory Response
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Integrin-mediated Signaling Pathway
Memory T Cell Extravasation
T Cell Activation
Receptor Clustering
Cell-cell Adhesion
Mitochondrion Organization
Epidermis Development
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Ubiquitination
Apoptotic Nuclear Changes
Keratinization
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Inflammatory Response
Protein Linear Polyubiquitination
Regulation Of CD40 Signaling Pathway
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Neutrophil degranulation
RUNX3 Regulates Immune Response and Cell Migration
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Neurexins and neuroligins
Drugs
Efalizumab
Antithymocyte immunoglobulin (rabbit)
Lovastatin
Simvastatin
Rosuvastatin
1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine
LFA703
(S)-2-((S)-3-isobutyl-2,5-dioxo-4-quinolin-3-ylmethyl-[1,4]diazepan-1yl)-N-methyl-3-naphtalen-2-yl-propionamide
7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile
3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline
Pitavastatin
Lifitegrast
Diseases
GWAS
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
27863252
32888494
)
Smooth-surface caries (
24556642
)
Ulcerative colitis (
23128233
28067908
)
White blood cell count (
27863252
32888494
)
Asthma (
31959851
32296059
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Serum metabolite levels (
23093944
)
Sum eosinophil basophil counts (
27863252
)
Interacting Genes
7 interacting genes:
F11R
ICAM1
ICAM3
ICAM5
PTPRC
RANBP9
SHARPIN
30 interacting genes:
ACTR2
ACTR3
FMR1
FXR1
ITGA1
ITGA2B
ITGA5
ITGAD
ITGAL
ITGAM
ITGB2
KRTAP6-2
KRTAP7-1
PPIL3
PTEN
RBCK1
RNF26
RNF31
SHANK1
SHANK2
SHANK3
TIAM1
TNF
TRAF1
TRIP13
TXN2
UBC
USP54
YOD1
ZBTB32
Entrez ID
3683
81858
HPRD ID
01079
15463
Ensembl ID
ENSG00000005844
ENSG00000179526
Uniprot IDs
B2RAL6
P20701
Q6PJD5
Q9H0F6
PDB IDs
1CQP
1DGQ
1LFA
1MJN
1MQ8
1MQ9
1MQA
1RD4
1T0P
1XDD
1XDG
1XUO
1ZON
1ZOO
1ZOP
2ICA
2K8O
2M3E
2O7N
3BN3
3BQM
3BQN
3E2M
3EOA
3EOB
3F74
3F78
3HI6
3M6F
3TCX
4IXD
5E6R
5E6S
5E6U
6BXB
6BXF
6BXJ
6CKB
7KC3
7KC5
7KC6
4EMO
5X0W
8K6P
Enriched GO Terms of Interacting Partners
?
Integrin Binding
Cell-cell Adhesion
T Cell Extravasation
Leukocyte Cell-cell Adhesion
Cell Adhesion
Cellular Extravasation
Establishment Of Endothelial Barrier
T Cell Migration
Endothelial Cell Development
Regulation Of ERK1 And ERK2 Cascade
Lymphocyte Migration
Regulation Of Intracellular Signal Transduction
Negative Regulation Of ERK1 And ERK2 Cascade
Plasma Membrane Raft Distribution
Virus Receptor Activity
Positive Regulation Of Intracellular Signal Transduction
Mononuclear Cell Migration
Regulation Of Leukocyte Mediated Cytotoxicity
Phagocytosis
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Hematopoietic Stem Cell Migration
Memory T Cell Extravasation
Symbiont Entry Into Host Cell
Epithelial Cell Development
Membrane Microdomain
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Membrane To Membrane Docking
T Cell Antigen Processing And Presentation
Regulation Of MAPK Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Biological Process Involved In Interaction With Host
Plasma Membrane
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Negative Regulation Of MAPK Cascade
DN2 Thymocyte Differentiation
Negative Regulation Of Inflammatory Response
Regulation Of Cytokine-mediated Signaling Pathway
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Positive Regulation Of Establishment Of Endothelial Barrier
Protein Localization To Bicellular Tight Junction
LUBAC Complex
Apoptotic Nuclear Changes
Regulation Of CD40 Signaling Pathway
Membrane Raft
T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Positive Regulation Of Cell Communication
Regulation Of Signal Transduction
Receptor-mediated Virion Attachment To Host Cell
Integrin Complex
Cell-matrix Adhesion
Cell-substrate Adhesion
Integrin-mediated Signaling Pathway
Synaptic Receptor Adaptor Activity
Cellular Extravasation
Dendritic Spine
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Heterotypic Cell-cell Adhesion
Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway
Regulation Of Nervous System Process
Leukocyte Cell-cell Adhesion
Integrin AlphaL-beta2 Complex
Integrin AlphaM-beta2 Complex
Social Behavior
Dendritic Spine Morphogenesis
Postsynaptic Density Organization
Signaling Receptor Activity
Vocalization Behavior
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
ICAM-3 Receptor Activity
Positive Regulation Of Neutrophil Degranulation
Meiotic Chromosome Movement Towards Spindle Pole
Cell Adhesion
Cell Surface
Postsynaptic Specialization Organization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Long-term Neuronal Synaptic Plasticity
Cognition
Modulation Of Chemical Synaptic Transmission
Negative Regulation Of Dopamine Metabolic Process
Microglial Cell Activation
LUBAC Complex
Ionotropic Glutamate Receptor Binding
Neuron Projection
Positive Regulation Of Excitatory Postsynaptic Potential
Dendritic Spine Organization
Leukocyte Activation Involved In Inflammatory Response
External Side Of Plasma Membrane
RNA Strand Annealing Activity
Negative Regulation Of Catecholamine Metabolic Process
Regulation Of Neurogenesis
Positive Regulation Of Neurogenesis
Positive Regulation Of Dendritic Spine Development
Positive Regulation Of DNA-binding Transcription Factor Activity
Postsynaptic Membrane
Signal Transduction
Intracellular Membraneless Organelle
Regulation Of Neutrophil Degranulation
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