INSIG1 and VCP

Number of citations of the paper that reports this interaction (PMID 16168377)
70

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

		INSIG1	VCP
Gene Name		insulin induced gene 1	valosin containing protein
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Proteasome Complex Hrd1p Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Cytosol Site Of Double-strand Break Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Receptor Binding Protein Binding ATP Binding Lipid Binding ATPase Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Binding Protein Complex Binding Deubiquitinase Activator Activity Identical Protein Binding ADP Binding Poly(A) RNA Binding Ubiquitin-specific Protease Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Metabolic Process Cell Proliferation Negative Regulation Of Steroid Biosynthetic Process SREBP Signaling Pathway Inner Ear Morphogenesis Middle Ear Morphogenesis Small Molecule Metabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Palate Development Cranial Suture Morphogenesis Negative Regulation Of Cargo Loading Into COPII-coated Vesicle	DNA Repair Double-strand Break Repair ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Translesion Synthesis ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Hexamerization Cellular Response To Heat Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Protein Homooligomerization Aggresome Assembly Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins	HSF1 activation Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog Cellular response to heat stress
Drugs
Diseases
GWAS		Formal thought disorder in schizophrenia ( 22648509)
Protein-Protein Interactions		6 interactors: HMGCR PSMA7 PSMC3 SCAP SREBF2 VCP	72 interactors: AMFR AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BRCA1 BRSK2 CAV1 CEP19 CRMP1 DERL1 DGCR6 DTNB FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LNX1 MAPK8IP2 NDRG1 NF1 NFKBIA NGLY1 NPLOC4 NSFL1C NUB1 OTULIN PLAA PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF19A RNF31 RNF8 RPL9 RPS6KA1 SH2D2A SIK2 STUB1 STX5 SUMO4 SVIP SYVN1 TOM1L1 TOMM34 UBE4A UBE4B UBOX5 UBQLN1 UBXN1 UBXN2A UBXN2B UBXN6 UFD1L VCPIP1 VCPKMT VIMP WAC WBSCR22 WDYHV1 WRN YOD1 YWHAZ ZFAND2B
Entrez ID		3638	7415
HPRD ID		03633	03013
Ensembl ID		ENSG00000186480	ENSG00000165280
Uniprot IDs		A4D2M9 F5H6P3 O15503	P55072 Q96IF9
PDB IDs		4J81	3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Steroid Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Small Molecule Metabolic Process Alcohol Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Ketone Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Apoptotic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Proteolysis Involved In Cellular Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Cell Death Cellular Protein Catabolic Process Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Cell Cycle Arrest	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Modification By Small Protein Conjugation Protein Ubiquitination Response To Stress Catabolic Process Protein Metabolic Process Protein Polyubiquitination Cellular Metabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Cellular Response To Topologically Incorrect Protein ER-nucleus Signaling Pathway Golgi Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Negative Regulation Of Cellular Protein Metabolic Process Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cellular Response To Unfolded Protein Programmed Cell Death Negative Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Signal Transduction Response To Stimulus Response To Unfolded Protein Negative Regulation Of Signaling
Tagcloud ?		amfr anchoring catalyzed dnas e3 eris facilitating herpes hsv interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing served simplex stimulator sting tank tbk1 uncovers	17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia
Tagcloud (Difference) ?		amfr anchoring catalyzed e3 eris facilitating herpes hsv interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing simplex stimulator sting tank tbk1 uncovers	17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent stoichiometric triskelia
Tagcloud (Intersection) ?		dnas served