INSIG1 and SREBF2

Number of citations of the paper that reports this interaction (PMID 12202038)
161

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		INSIG1	SREBF2
Gene Name		insulin induced gene 1	sterol regulatory element binding transcription factor 2
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex
	Molecular Function	Protein Binding	C-8 Sterol Isomerase Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Metabolic Process Cell Proliferation Negative Regulation Of Steroid Biosynthetic Process SREBP Signaling Pathway Inner Ear Morphogenesis Middle Ear Morphogenesis Small Molecule Metabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Palate Development Cranial Suture Morphogenesis Negative Regulation Of Cargo Loading Into COPII-coated Vesicle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Lipid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cholesterol Storage Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Low-density Lipoprotein Particle Cellular Response To Laminar Fluid Shear Stress Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cholesterol Efflux Regulation Of Cholesterol Homeostasis
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins	Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Formal thought disorder in schizophrenia ( 22648509)
Protein-Protein Interactions		6 interactors: HMGCR PSMA7 PSMC3 SCAP SREBF2 VCP	48 interactors: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL3 GOLGB1 HDAC3 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LZTR1 MAPK1 MAPK3 MRPS6 NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SREBF1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX
Entrez ID		3638	6721
HPRD ID		03633	02726
Ensembl ID		ENSG00000186480	ENSG00000198911
Uniprot IDs		A4D2M9 F5H6P3 O15503	Q12772
PDB IDs		4J81	1UKL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Steroid Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Small Molecule Metabolic Process Alcohol Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Ketone Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Apoptotic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Proteolysis Involved In Cellular Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Cell Death Cellular Protein Catabolic Process Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Cell Cycle Arrest	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Signaling Viral Process RNA Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Protein Sumoylation Cell Communication Negative Regulation Of Biosynthetic Process Response To Organic Substance Regulation Of Metabolic Process Biosynthetic Process Cellular Response To Organic Substance Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Cellular Response To Stress Cell Surface Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Rhythmic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		amfr anchoring catalyzed dnas e3 eris facilitating herpes hsv interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing served simplex stimulator sting tank tbk1 uncovers	33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous
Tagcloud (Difference) ?		amfr anchoring catalyzed dnas e3 eris facilitating herpes hsv interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing served simplex stimulator sting tank tbk1 uncovers	33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous
Tagcloud (Intersection) ?