INSIG1 and HMGCR

Number of citations of the paper that reports this interaction (PMID 12535518)
61

Data Source:
HPRD (in vivo)

		INSIG1	HMGCR
Gene Name		insulin induced gene 1	3-hydroxy-3-methylglutaryl-CoA reductase
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Hydroxymethylglutaryl-CoA Reductase Activity Protein Homodimerization Activity Coenzyme Binding NADPH Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Metabolic Process Cell Proliferation Negative Regulation Of Steroid Biosynthetic Process SREBP Signaling Pathway Inner Ear Morphogenesis Middle Ear Morphogenesis Small Molecule Metabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Palate Development Cranial Suture Morphogenesis Negative Regulation Of Cargo Loading Into COPII-coated Vesicle	Cholesterol Biosynthetic Process Ubiquinone Metabolic Process Aging Response To Nutrient Isoprenoid Biosynthetic Process Visual Learning Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Coenzyme A Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of MAP Kinase Activity Cellular Lipid Metabolic Process Small Molecule Metabolic Process Myoblast Differentiation Response To Ethanol Negative Regulation Of Vasodilation Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Smooth Muscle Cell Proliferation Protein Tetramerization Oxidation-reduction Process Negative Regulation Of Wound Healing Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins
Drugs			NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa Adenosine-5\'-Diphosphate 2\'-Monophosphoadenosine 5\'-Diphosphoribose 3-Hydroxy-3-Methyl-Glutaric Acid 1,4-Dithiothreitol Mevastatin 7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID Pitavastatin
Diseases
GWAS		Formal thought disorder in schizophrenia ( 22648509)	Body mass index ( 20935630) Cholesterol, total ( 19060911 20686565) LDL cholesterol ( 18802019 18193044 20864672 19060906 19060911 20686565) Metabolite levels ( 21909109) Quantitative traits ( 19197348)
Protein-Protein Interactions		6 interactors: HMGCR PSMA7 PSMC3 SCAP SREBF2 VCP	4 interactors: ARHGAP1 INSIG1 PRKACA STARD13
Entrez ID		3638	3156
HPRD ID		03633	00836
Ensembl ID		ENSG00000186480	ENSG00000113161
Uniprot IDs		A4D2M9 F5H6P3 O15503	P04035
PDB IDs		4J81	1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Steroid Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Small Molecule Metabolic Process Alcohol Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Ketone Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Apoptotic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Proteolysis Involved In Cellular Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Cell Death Cellular Protein Catabolic Process Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Cell Cycle Arrest	Triglyceride Metabolic Process Neutral Lipid Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Positive Regulation Of Hydrolase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Regulation Of Cargo Loading Into COPII-coated Vesicle Positive Regulation Of Catalytic Activity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Glycerolipid Metabolic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Transport Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Intracellular Signal Transduction Positive Regulation Of Macrophage Differentiation Cranial Suture Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Transport Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Positive Regulation Of Protein Export From Nucleus SREBP Signaling Pathway Cell Communication By Electrical Coupling Signal Transduction Activation Of Protein Kinase A Activity Response To Sterol Depletion Regulation Of Cellular Ketone Metabolic Process Craniofacial Suture Morphogenesis Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Sperm Capacitation Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To Epinephrine Positive Regulation Of Blood Vessel Endothelial Cell Migration Skeletal System Development Signaling Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Tagcloud ?		amfr anchoring catalyzed dnas e3 eris facilitating herpes hsv interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing served simplex stimulator sting tank tbk1 uncovers	7b alteration alters bh3 biosynthesis cholesterol chop clues downregulation ebp emerged foxj2 h460 hmgcs1 idi1 inverse let lna mirna mirnas mirnome nac nci played respective scavenger silencing stat6 utr
Tagcloud (Difference) ?		amfr anchoring catalyzed dnas e3 eris facilitating herpes hsv interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing served simplex stimulator sting tank tbk1 uncovers	7b alteration alters bh3 biosynthesis cholesterol chop clues downregulation ebp emerged foxj2 h460 hmgcs1 idi1 inverse let lna mirna mirnas mirnome nac nci played respective scavenger silencing stat6 utr
Tagcloud (Intersection) ?