INSIG1 and BDKRB1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		INSIG1	BDKRB1
Name		insulin induced gene 1	bradykinin receptor B1
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane SREBP-SCAP-Insig Complex	Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	Protein Binding Oxysterol Binding Lipid Binding Protein Sequestering Activity	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Biosynthetic Process Response To Sterol Depletion Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway Cellular Response To Sterol SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Cholesterol Homeostasis Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Protein Maturation Roof Of Mouth Development Cranial Suture Morphogenesis Negative Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Cargo Loading Into COPII-coated Vesicle	Positive Regulation Of Leukocyte Migration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Mechanical Stimulus Cell Migration Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		None	Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		Bladder cancer (smoking interaction) ( 24662972 ) Diverticular disease ( 30177863 ) Energy expenditure (24h) ( 28476931 ) Formal thought disorder in schizophrenia ( 22648509 ) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681 ) Plasma anti-thyroglobulin levels ( 29678681 ) Triiodothyronine levels and thyroxine levels ( 30843173 )	Metabolite levels ( 23823483 )
Novel Interactors		1 novel interactors: ELOC	2 novel interactors: DNAJB13 EVL
Interacting Genes		11 interacting genes: AQP6 BDKRB1 HMGCR HTR2B PCK1 PSMA7 PSMC3 SCAP SREBF2 TMEM237 VCP	32 interacting genes: CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C LTAP1 MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22
Entrez ID		3638	623
HPRD ID		03633	02639
Ensembl ID		ENSG00000186480	ENSG00000100739
Uniprot IDs		A4D2M9 F5H6P3 O15503	P46663
PDB IDs		4J81	7EIB
GO Terms Enriched among Interactors		Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Metabolic Process Regulation Of Lipid Biosynthetic Process Proteasome Complex SREBP Signaling Pathway Cellular Response To Sterol Depletion Negative Regulation Of Amyloid-beta Clearance Regulation Of Steroid Biosynthetic Process Response To Sterol Depletion Alcohol Metabolic Process Regulation Of Steroid Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Regulation Of Amyloid-beta Clearance Endoplasmic Reticulum ER-nucleus Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Steroid Metabolic Process Modification-dependent Protein Catabolic Process Nitrate Transmembrane Transporter Activity Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Serine Kinase Activity (using GTP As Donor) Flavin Adenine Dinucleotide Catabolic Process SREBP-SCAP Complex ER To Golgi Transport Vesicle Membrane Positive Regulation Of Biosynthetic Process Proteolysis Involved In Protein Catabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Bradykinin Receptor Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity Phosphoenolpyruvate Carboxykinase Activity Glycerol Biosynthetic Process From Pyruvate Propionate Catabolic Process C-8 Sterol Isomerase Activity VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Response To Vitamin B3 Regulation Of Protein Catabolic Process Small Molecule Metabolic Process	Endoplasmic Reticulum Membrane Membrane Ferrous Iron Transmembrane Transporter Activity Brain Development Iron Ion Transmembrane Transporter Activity Negative Regulation Of Transport Profilin Binding