INSIG1 and SCAP

Number of citations of the paper that reports this interaction (PubMedID 32432943)
80

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		INSIG1	SCAP
Description		insulin induced gene 1	SREBF chaperone
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane SREBP-SCAP-Insig Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle SREBP-SCAP Complex Protein-containing Complex
	Molecular Function	Protein Binding Oxysterol Binding Lipid Binding Protein Sequestering Activity	Protein Binding Lipid Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Biosynthetic Process Response To Sterol Depletion Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway Cellular Response To Sterol SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Cholesterol Homeostasis Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Protein Maturation Roof Of Mouth Development Cranial Suture Morphogenesis Negative Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Cargo Loading Into COPII-coated Vesicle	Response To Hypoxia Lipid Metabolic Process Immune Response Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Fatty Acid Metabolic Process Response To Insulin SREBP Signaling Pathway Response To Vitamin B3 Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Diverticular disease ( 30177863) Energy expenditure (24h) ( 28476931) Formal thought disorder in schizophrenia ( 22648509) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Triiodothyronine levels and thyroxine levels ( 30843173)	Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		11 interacting genes: AQP6 BDKRB1 HMGCR HTR2B PCK1 PSMA7 PSMC3 SCAP SREBF2 TMEM237 VCP	5 interacting genes: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2
Entrez ID		3638	22937
HPRD ID		03633	03300
Ensembl ID		ENSG00000186480	ENSG00000114650
Uniprot IDs		A4D2M9 F5H6P3 O15503	B7Z6H0 Q12770
PDB IDs		4J81	6M49 7ETW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Metabolic Process Regulation Of Lipid Biosynthetic Process Proteasome Complex SREBP Signaling Pathway Cellular Response To Sterol Depletion Negative Regulation Of Amyloid-beta Clearance Regulation Of Steroid Biosynthetic Process Response To Sterol Depletion Alcohol Metabolic Process Regulation Of Steroid Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Regulation Of Amyloid-beta Clearance Endoplasmic Reticulum ER-nucleus Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Steroid Metabolic Process Modification-dependent Protein Catabolic Process Nitrate Transmembrane Transporter Activity Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Serine Kinase Activity (using GTP As Donor) Flavin Adenine Dinucleotide Catabolic Process SREBP-SCAP Complex ER To Golgi Transport Vesicle Membrane Positive Regulation Of Biosynthetic Process Proteolysis Involved In Protein Catabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Bradykinin Receptor Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity Phosphoenolpyruvate Carboxykinase Activity Glycerol Biosynthetic Process From Pyruvate Propionate Catabolic Process C-8 Sterol Isomerase Activity VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Response To Vitamin B3 Regulation Of Protein Catabolic Process Small Molecule Metabolic Process	SREBP-SCAP-Insig Complex SREBP Signaling Pathway Cellular Response To Sterol Depletion Response To Sterol Depletion Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cargo Loading Into COPII-coated Vesicle Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Biosynthetic Process ER-nucleus Signaling Pathway SREBP-SCAP Complex Retention In Endoplasmic Reticulum Positive Regulation Of Steroid Metabolic Process Negative Regulation Of SREBP Signaling Pathway Regulation Of Cholesterol Metabolic Process Cranial Suture Morphogenesis Regulation Of SREBP Signaling Pathway Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of Lipid Biosynthetic Process Oxysterol Binding Regulation Of Steroid Metabolic Process Craniofacial Suture Morphogenesis Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Middle Ear Morphogenesis Positive Regulation Of Lipid Metabolic Process NLS-bearing Protein Import Into Nucleus Negative Regulation Of Steroid Biosynthetic Process Embryonic Morphogenesis Positive Regulation Of Small Molecule Metabolic Process Lung Morphogenesis Negative Regulation Of Steroid Metabolic Process Cholesterol Biosynthetic Process Regulation Of Lipid Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Sterol Biosynthetic Process Maintenance Of Protein Localization In Organelle Protein Sequestering Activity Regulation Of Fatty Acid Biosynthetic Process Steroid Metabolic Process Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Maintenance Of Protein Location In Cell Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Vacuole-isolation Membrane Contact Site ER To Golgi Transport Vesicle Membrane Inner Ear Morphogenesis Triglyceride Metabolic Process Alcohol Metabolic Process Maintenance Of Protein Location
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