IGFBP3 and CTSG

Number of citations of the paper that reports this interaction (PMID 10512690)
10

Data Source:
HPRD (in vivo, in vitro)

		IGFBP3	CTSG
Gene Name		insulin-like growth factor binding protein 3	cathepsin G
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Insulin-like Growth Factor Binding Protein Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface Secretory Granule Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding	Serine-type Endopeptidase Activity Heparin Binding Peptidase Activity
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	Angiotensin Maturation Proteolysis Immune Response Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Response To Lipopolysaccharide Negative Regulation Of Growth Of Symbiont In Host Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Fungus Neutrophil Mediated Killing Of Gram-positive Bacterium
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix
Drugs		Mecasermin	Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS		Insulin-like growth factors ( 21216879) Major depressive disorder ( 23377640) Ventricular conduction ( 21076409)
Protein-Protein Interactions		28 interactors: ADAM12 CAV1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 LTBP1 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 RXRA TF	28 interactors: AGT C3 CAMP CASP7 CXCL12 CXCR4 ERBB2IP F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NL PARP1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		3486	1511
HPRD ID		00899	00289
Ensembl ID		ENSG00000146674	ENSG00000100448
Uniprot IDs		B3KPF0 B3KWK7 P17936	P08311
PDB IDs			1AU8 1CGH 1KYN 1T32
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Hemostasis Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Fibrinolysis Platelet Activation Leukocyte Migration Positive Regulation Of Fibrinolysis Platelet Degranulation Response To Stimulus Proteolysis Fibrinolysis Exocrine Pancreas Development Regulation Of Blood Coagulation Response To Stress Regulation Of Protein Metabolic Process Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Anatomical Structure Morphogenesis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Wound Healing Prostate Gland Development Organ Morphogenesis Acute Inflammatory Response Vasculature Development Immune System Process Movement Of Cell Or Subcellular Component Factor XII Activation Cardiovascular System Development Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Processing Locomotion Cell Activation Regulation Of Mitotic Nuclear Division Prostate Gland Epithelium Morphogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis	Cell Activation Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Inflammatory Response Blood Coagulation Hemostasis Wound Healing Response To Wounding Negative Regulation Of Endopeptidase Activity Response To Stress Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Platelet Activation Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Thrombin Receptor Signaling Pathway Regulation Of Protein Processing Response To Stimulus Regulation Of Cellular Protein Metabolic Process Defense Response Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Migration Platelet Degranulation Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Transport Regulation Of Catalytic Activity Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Regulation Of Chemotaxis Response To Cytokine Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Blood Circulation Response To Biotic Stimulus Secretion By Cell Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Secretion Positive Regulation Of Cell Migration Cellular Chemical Homeostasis Positive Regulation Of Cell Motility
Tagcloud ?		bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts	aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram
Tagcloud (Difference) ?		bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts	aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram
Tagcloud (Intersection) ?