IGFBP3 and GPI

Number of citations of the paper that reports this interaction (PubMedID 15059907)
0

Data Source:
HPRD (in vitro)

		IGFBP3	GPI
Description		insulin like growth factor binding protein 3	glucose-6-phosphate isomerase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Secretory Granule Lumen Ciliary Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding	Glucose-6-phosphate Isomerase Activity Cytokine Activity Protein Binding Growth Factor Activity Isomerase Activity Ubiquitin Protein Ligase Binding Monosaccharide Binding Carbohydrate Derivative Binding
	Biological Process	MAPK Cascade Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Growth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	In Utero Embryonic Development Mesoderm Formation Positive Regulation Of Immunoglobulin Production Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Glycolytic Process Humoral Immune Response Signal Transduction Hemostasis Learning Or Memory Positive Regulation Of Endothelial Cell Migration Response To Estradiol Response To Progesterone Response To Testosterone Erythrocyte Homeostasis Response To Immobilization Stress Response To Muscle Stretch Glucose Homeostasis Negative Regulation Of Apoptotic Process Response To Cadmium Ion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Carbohydrate Derivative Metabolic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation	TP53 Regulates Metabolic Genes Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs		Alitretinoin Mecasermin	alpha-D-glucose 6-phosphate 6-phospho-D-gluconic acid 5-phospho-D-arabinohydroxamic acid D-glucitol 6-phosphate 5-Phosphoarabinonic Acid Glucose-6-Phosphate D-erythrose 4-phosphate Fructose-6-phosphate Copper Artenimol
Diseases			Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 23696881 30072576) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418 28498854 27841878) FEV1 ( 30804560) Height ( 33713608 25282103 31562340) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 30487518 29403010 28739976 28498854 28135244 27841878 27618448) QRS duration ( 21076409 27577874) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618448 27618447) Tonsillectomy ( 28928442 27182965) Venous thromboembolism ( 26888256) Waist circumference adjusted for body mass index ( 34021172)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular volume ( 32888494)
Interacting Genes		38 interacting genes: ADAM12 AURKA BMPR1A BUB1 CAV1 CCND1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FBXW7 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 KRAS LTBP1 MLH3 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RAD54B RXRA STK11 TF	6 interacting genes: AMFR CSNK2A1 IGFBP3 LINC01554 PARP14 PCNA
Entrez ID		3486	2821
HPRD ID		00899	01394
Ensembl ID		ENSG00000146674	ENSG00000105220
Uniprot IDs		B3KPF0 P17936	A0A2U3TZU2 B4DE36 P06744
PDB IDs		7WRQ	1IAT 1IRI 1JIQ 1JLH 1NUH 6XUH 6XUI 8BBH 8P2K 9FCW 9FHF 9FKC 9FKF
Enriched GO Terms of Interacting Partners?		Extracellular Region Peptidase Activity Endopeptidase Activity Serine-type Endopeptidase Activity Extracellular Matrix Extracellular Space Cell Surface Receptor Signaling Pathway Response To UV-A Proteolysis Positive Regulation Of Signal Transduction Extracellular Matrix Disassembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Stress Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Collagen Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To UV-A Protein Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Apoptotic Process Response To UV Regulation Of Cell Population Proliferation Extracellular Matrix Organization Extracellular Structure Organization Biological Process Involved In Interaction With Symbiont Regulation Of Epithelial Cell Proliferation Positive Regulation Of Multicellular Organismal Process Cellular Response To UV Regulation Of Signal Transduction Metalloendopeptidase Activity Collagen Catabolic Process Regulation Of Programmed Cell Death Chemical Homeostasis Gland Development Homeostatic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Cellular Component Organization Cellular Response To Light Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Developmental Process Response To Radiation Hydrolase Activity Glucose Homeostasis	Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Stress BAT3 Complex Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Growth Regulation Of Growth Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Metabolic Process Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Protein Phosphorylation Insulin-like Growth Factor Binding Protein Complex Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor Ternary Complex Negative Regulation Of Phosphorylation PCNA Complex Positive Regulation Of Deoxyribonuclease Activity PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Aggrephagy Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Type II Interferon-mediated Signaling Pathway Derlin-1 Retrotranslocation Complex Insulin-like Growth Factor II Binding Regulation Of DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of SREBP Signaling Pathway Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cell Death Double-strand Break Repair Via Classical Nonhomologous End Joining Apoptotic Process Rhythmic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Programmed Cell Death Negative Regulation Of Collateral Sprouting
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