IGFBP3 and BMPR1A

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		IGFBP3	BMPR1A
Description		insulin like growth factor binding protein 3	bone morphogenetic protein receptor type 1A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex	Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding BMP Receptor Activity
	Biological Process	MAPK Cascade Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Growth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	Angiogenesis Osteoblast Differentiation In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Intracellular Iron Ion Homeostasis Immune Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Ectoderm Development Nervous System Development Endoderm Development Heart Development Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Negative Regulation Of Smooth Muscle Cell Migration Central Nervous System Neuron Differentiation Pituitary Gland Development Neural Plate Mediolateral Regionalization Cell Differentiation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta2 Production Somatic Stem Cell Population Maintenance Hindlimb Morphogenesis Dorsal Aorta Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Embryonic Morphogenesis Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Negative Regulation Of Muscle Cell Differentiation Cartilage Development Roof Of Mouth Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Neural Plate Pattern Specification Heart Formation Atrioventricular Node Cell Development Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Dendrite Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Fibrous Ring Of Heart Morphogenesis Regulation Of Neural Crest Cell Differentiation Anti-Mullerian Hormone Receptor Signaling Pathway Regulation Of Cellular Senescence
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation	Signaling by BMP
Drugs		Alitretinoin Mecasermin	Dibotermin alfa
Diseases			Juvenile polyposis syndrome Hereditary mixed polyposis syndrome
GWAS		Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 23696881 30072576) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418 28498854 27841878) FEV1 ( 30804560) Height ( 33713608 25282103 31562340) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 30487518 29403010 28739976 28498854 28135244 27841878 27618448) QRS duration ( 21076409 27577874) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618448 27618447) Tonsillectomy ( 28928442 27182965) Venous thromboembolism ( 26888256) Waist circumference adjusted for body mass index ( 34021172)	Apolipoprotein A1 levels ( 32203549) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		38 interacting genes: ADAM12 AURKA BMPR1A BUB1 CAV1 CCND1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FBXW7 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 KRAS LTBP1 MLH3 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RAD54B RXRA STK11 TF	45 interacting genes: ACVR1 ALDOB AOPEP BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 CDK8 CRIPTO CTSV FANCC FBP1 FBP2 FKBP1A FKBP1B GALNT12 GDF5 GDF6 GDF9 HOXC8 HRAS IGFBP3 MAP2K1 MSANTD3 NEDD4 NEDD4L OTUB1 RASA1 SEC61B SF3B4 SFRP2 SFRP4 SMAD1 TAB1 TGFB1 TGFBRAP1 TRMO USP15 XPA ZMYND11 ZNF189
Entrez ID		3486	657
HPRD ID		00899	03192
Ensembl ID		ENSG00000146674	ENSG00000107779
Uniprot IDs		B3KPF0 P17936	P36894
PDB IDs		7WRQ	1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?		Extracellular Region Peptidase Activity Endopeptidase Activity Serine-type Endopeptidase Activity Extracellular Matrix Extracellular Space Cell Surface Receptor Signaling Pathway Response To UV-A Proteolysis Positive Regulation Of Signal Transduction Extracellular Matrix Disassembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Stress Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Collagen Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To UV-A Protein Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Apoptotic Process Response To UV Regulation Of Cell Population Proliferation Extracellular Matrix Organization Extracellular Structure Organization Biological Process Involved In Interaction With Symbiont Regulation Of Epithelial Cell Proliferation Positive Regulation Of Multicellular Organismal Process Cellular Response To UV Regulation Of Signal Transduction Metalloendopeptidase Activity Collagen Catabolic Process Regulation Of Programmed Cell Death Chemical Homeostasis Gland Development Homeostatic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Cellular Component Organization Cellular Response To Light Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Developmental Process Response To Radiation Hydrolase Activity Glucose Homeostasis	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Positive Regulation Of Signal Transduction Cellular Response To BMP Stimulus Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Cartilage Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Intracellular Signal Transduction Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development BMP Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Ossification Anatomical Structure Morphogenesis Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Signaling Regulation Of Cell Communication Regulation Of Ossification Regulation Of Bone Mineralization Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Cytokine Activity Regulation Of Primary Metabolic Process Pattern Specification Process Regulation Of Nucleobase-containing Compound Metabolic Process Animal Organ Morphogenesis Response To Growth Factor Mesenchyme Development Positive Regulation Of Epithelial To Mesenchymal Transition Endocardial Cushion Formation Signal Transduction Regulation Of RNA Metabolic Process Heart Development
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