IGFBP3 and LTBP1

Number of citations of the paper that reports this interaction (PMID 12962157)
5

Data Source:
HPRD (two hybrid)

		IGFBP3	LTBP1
Gene Name		insulin-like growth factor binding protein 3	latent transforming growth factor beta binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Insulin-like Growth Factor Binding Protein Complex Extracellular Vesicular Exosome	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix Protein Complex
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding	Transforming Growth Factor Beta-activated Receptor Activity Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding Microfibril Binding
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Matrix Organization Sequestering Of TGFbeta In Extracellular Matrix
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Molecules associated with elastic fibres Elastic fibre formation
Drugs		Mecasermin
Diseases
GWAS		Insulin-like growth factors ( 21216879) Major depressive disorder ( 23377640) Ventricular conduction ( 21076409)	Height ( 20881960 19893584 23563607 20189936) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Immune response to smallpox vaccine (IL-6) ( 22610502)
Protein-Protein Interactions		28 interactors: ADAM12 CAV1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 LTBP1 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 RXRA TF	9 interactors: ATN1 CACNA1A FBN1 FBN2 FN1 IGFBP3 ITGB5 TGFB1 TGM2
Entrez ID		3486	4052
HPRD ID		00899	01039
Ensembl ID		ENSG00000146674	ENSG00000049323
Uniprot IDs		B3KPF0 B3KWK7 P17936	B7ZLY3 Q14766
PDB IDs			1KSQ
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Hemostasis Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Fibrinolysis Platelet Activation Leukocyte Migration Positive Regulation Of Fibrinolysis Platelet Degranulation Response To Stimulus Proteolysis Fibrinolysis Exocrine Pancreas Development Regulation Of Blood Coagulation Response To Stress Regulation Of Protein Metabolic Process Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Anatomical Structure Morphogenesis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Wound Healing Prostate Gland Development Organ Morphogenesis Acute Inflammatory Response Vasculature Development Immune System Process Movement Of Cell Or Subcellular Component Factor XII Activation Cardiovascular System Development Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Processing Locomotion Cell Activation Regulation Of Mitotic Nuclear Division Prostate Gland Epithelium Morphogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis	Extracellular Matrix Organization Extracellular Structure Organization Sequestering Of TGFbeta In Extracellular Matrix Developmental Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Endoderm Development Extracellular Matrix Disassembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Extracellular Negative Regulation Of Signal Transduction Anatomical Structure Development Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Anatomical Structure Morphogenesis Endodermal Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Myoblast Differentiation Positive Regulation Of Biomineral Tissue Development Salivary Gland Morphogenesis Regulation Of Cell Differentiation Peptide Cross-linking System Development Salivary Gland Development Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Cell Differentiation Endoderm Formation Exocrine System Development Exocytosis Regulation Of Cell Growth Regulation Of Signaling Cellular Component Assembly Platelet Degranulation Regulation Of Bone Mineralization Cellular Metal Ion Homeostasis Cerebellar Molecular Layer Development Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Cell Death Death Negative Regulation Of Signal Transduction Positive Regulation Of Muscle Cell Differentiation Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis
Tagcloud ?		bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts	besides bioactive bioinformatics btb btbd3 candidate connectivity cul3 degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Difference) ?		bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts	besides bioactive bioinformatics btb btbd3 candidate connectivity cul3 degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Intersection) ?