IGFBP3 and IGF2

Number of citations of the paper that reports this interaction (PMID 9446566)
12

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		IGFBP3	IGF2
Gene Name		insulin-like growth factor binding protein 3	insulin-like growth factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Insulin-like Growth Factor Binding Protein Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Receptor Activator Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	Skeletal System Development Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Platelet Degranulation Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription, DNA-templated Multicellular Organismal Development Female Pregnancy Blood Coagulation Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Radiation Organ Morphogenesis Platelet Activation Exocrine Pancreas Development Response To Nutrient Levels Response To Estradiol Response To Nicotine Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Activated T Cell Proliferation Response To Drug Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Receptor Activity Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	IRS-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Response to elevated platelet cytosolic Ca2+ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R Platelet degranulation Platelet activation, signaling and aggregation IGF1R signaling cascade
Drugs		Mecasermin
Diseases
GWAS		Insulin-like growth factors ( 21216879) Major depressive disorder ( 23377640) Ventricular conduction ( 21076409)	DNA methylation (variation) ( 23725790) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Prostate cancer ( 19767753)
Protein-Protein Interactions		28 interactors: ADAM12 CAV1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 LTBP1 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 RXRA TF	22 interactors: BAG6 FAF1 GPC3 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 NOV PCSK4 PLG RBPMS TF VTN WISP2
Entrez ID		3486	3481
HPRD ID		00899	00939
Ensembl ID		ENSG00000146674	ENSG00000167244
Uniprot IDs		B3KPF0 B3KWK7 P17936	P01344
PDB IDs			1GF2 1IGL 2L29 2V5P 3E4Z 3KR3
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Hemostasis Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Fibrinolysis Platelet Activation Leukocyte Migration Positive Regulation Of Fibrinolysis Platelet Degranulation Response To Stimulus Proteolysis Fibrinolysis Exocrine Pancreas Development Regulation Of Blood Coagulation Response To Stress Regulation Of Protein Metabolic Process Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Anatomical Structure Morphogenesis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Wound Healing Prostate Gland Development Organ Morphogenesis Acute Inflammatory Response Vasculature Development Immune System Process Movement Of Cell Or Subcellular Component Factor XII Activation Cardiovascular System Development Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Processing Locomotion Cell Activation Regulation Of Mitotic Nuclear Division Prostate Gland Epithelium Morphogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis	Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Regulation Of Cellular Component Organization Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Developmental Process Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Regulation Of Signaling Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Carbohydrate Metabolic Process Regulation Of Cell Migration Regulation Of Phosphorylation Reproductive Process Regulation Of Cell Motility Exocrine Pancreas Development Exocrine System Development Cellular Protein Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Response To Stimulus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Organonitrogen Compound Regulation Of Cellular Process Male Sex Determination Anatomical Structure Development Tissue Development Negative Regulation Of Smooth Muscle Cell Migration Protein Tetramerization Response To Insulin Response To Hormone Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Kinase B Signaling
Tagcloud ?		bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts	affects biological blast carrying cdna cecum crossed deleted disrupted excess exclusively igf2r involve mannose must organ organs overexpressing paternal phenotypes proteolytic sdeltaigf2r sigf2r slow solely soluble stomach transgenics transmembrane
Tagcloud (Difference) ?		bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts	affects biological blast carrying cdna cecum crossed deleted disrupted excess exclusively igf2r involve mannose must organ organs overexpressing paternal phenotypes proteolytic sdeltaigf2r sigf2r slow solely soluble stomach transgenics transmembrane
Tagcloud (Intersection) ?