IGFBP3 and IGFALS

Number of citations of the paper that reports this interaction (PubMedID 9497324)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		IGFBP3	IGFALS
Description		insulin like growth factor binding protein 3	insulin like growth factor binding protein acid labile subunit
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex	Extracellular Region Extracellular Space Insulin-like Growth Factor Ternary Complex Extracellular Exosome
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding	Insulin-like Growth Factor Binding Signaling Receptor Activity
	Biological Process	MAPK Cascade Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Growth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	Cell Adhesion Signal Transduction
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Alitretinoin Mecasermin	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 23696881 30072576) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418 28498854 27841878) FEV1 ( 30804560) Height ( 33713608 25282103 31562340) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 30487518 29403010 28739976 28498854 28135244 27841878 27618448) QRS duration ( 21076409 27577874) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618448 27618447) Tonsillectomy ( 28928442 27182965) Venous thromboembolism ( 26888256) Waist circumference adjusted for body mass index ( 34021172)	Blood protein levels ( 30072576) Insulin-like growth factors ( 21216879) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		38 interacting genes: ADAM12 AURKA BMPR1A BUB1 CAV1 CCND1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FBXW7 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 KRAS LTBP1 MLH3 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RAD54B RXRA STK11 TF	4 interacting genes: IGF1 IGFBP3 IGFBP5 PDCD6
Entrez ID		3486	3483
HPRD ID		00899	03290
Ensembl ID		ENSG00000146674	ENSG00000099769
Uniprot IDs		B3KPF0 P17936	P35858 Q8TAY0
PDB IDs		7WRQ	7WRQ
Enriched GO Terms of Interacting Partners?		Extracellular Region Peptidase Activity Endopeptidase Activity Serine-type Endopeptidase Activity Extracellular Matrix Extracellular Space Cell Surface Receptor Signaling Pathway Response To UV-A Proteolysis Positive Regulation Of Signal Transduction Extracellular Matrix Disassembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Stress Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Collagen Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To UV-A Protein Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Apoptotic Process Response To UV Regulation Of Cell Population Proliferation Extracellular Matrix Organization Extracellular Structure Organization Biological Process Involved In Interaction With Symbiont Regulation Of Epithelial Cell Proliferation Positive Regulation Of Multicellular Organismal Process Cellular Response To UV Regulation Of Signal Transduction Metalloendopeptidase Activity Collagen Catabolic Process Regulation Of Programmed Cell Death Chemical Homeostasis Gland Development Homeostatic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Cellular Component Organization Cellular Response To Light Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Developmental Process Response To Radiation Hydrolase Activity Glucose Homeostasis	Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Migration Insulin-like Growth Factor II Binding Osteoblast Differentiation Insulin-like Growth Factor Binding Regulation Of Smooth Muscle Cell Proliferation Insulin-like Growth Factor I Binding Epithelial Cell Proliferation Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Fibronectin Binding Negative Regulation Of Smooth Muscle Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Growth Factor Binding Lung Alveolus Development Negative Regulation Of Signal Transduction Regulation Of Cell Growth Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Population Proliferation Striated Muscle Cell Differentiation Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Tissue Remodeling Positive Regulation Of Cell Migration Response To Heat Positive Regulation Of Cell Motility Epithelial To Mesenchymal Transition Negative Regulation Of Protein Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Growth Positive Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Regulation Of Glucose Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Muscle Cell Differentiation Negative Regulation Of Oocyte Development Mesenchymal Cell Differentiation Negative Regulation Of Skeletal Muscle Hypertrophy
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