IGFBP3 and ADAM12

Number of citations of the paper that reports this interaction (PMID 10849447)
28

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		IGFBP3	ADAM12
Gene Name		insulin-like growth factor binding protein 3	ADAM metallopeptidase domain 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Insulin-like Growth Factor Binding Protein Complex Extracellular Vesicular Exosome	Extracellular Region Nucleoplasm Mitochondrion Plasma Membrane Integral Component Of Membrane
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Myoblast Fusion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Signaling by EGFR Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs		Mecasermin
Diseases
GWAS		Insulin-like growth factors ( 21216879) Major depressive disorder ( 23377640) Ventricular conduction ( 21076409)	Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Protein-Protein Interactions		28 interactors: ADAM12 CAV1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 LTBP1 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 RXRA TF	11 interactors: ACTN2 EGF FSTL3 GRB2 IGFBP3 IGFBP5 PACSIN3 PIK3R1 SH3D19 SRC YES1
Entrez ID		3486	8038
HPRD ID		00899	04092
Ensembl ID		ENSG00000146674	ENSG00000148848
Uniprot IDs		B3KPF0 B3KWK7 P17936	A8K6G4 O43184
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Hemostasis Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Fibrinolysis Platelet Activation Leukocyte Migration Positive Regulation Of Fibrinolysis Platelet Degranulation Response To Stimulus Proteolysis Fibrinolysis Exocrine Pancreas Development Regulation Of Blood Coagulation Response To Stress Regulation Of Protein Metabolic Process Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Anatomical Structure Morphogenesis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Wound Healing Prostate Gland Development Organ Morphogenesis Acute Inflammatory Response Vasculature Development Immune System Process Movement Of Cell Or Subcellular Component Factor XII Activation Cardiovascular System Development Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Processing Locomotion Cell Activation Regulation Of Mitotic Nuclear Division Prostate Gland Epithelium Morphogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis	Blood Coagulation Hemostasis Platelet Activation Vesicle-mediated Transport T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Regulation Of Cellular Component Organization Response To Wounding Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Carbohydrate Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Smooth Muscle Cell Migration Immune Response-regulating Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Organonitrogen Compound Response To Fibroblast Growth Factor Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Leukocyte Migration Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Phagocytosis Regulation Of Cell Adhesion Negative Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cell Activation Positive Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Regulation Of Immune System Process Cellular Response To Peptide
Tagcloud ?		bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts	alpha1 anchoring balanced brdu cct ccts cytotrophoblasts eclampsia evt evts exaggerated explant extravillous fibronectin floating hes1 labelling maml notch outgrowth overgrowth placental rbpjkappa sirnas trimester trophoblast trophoblasts villi villous
Tagcloud (Difference) ?		bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts	alpha1 anchoring balanced brdu cct ccts cytotrophoblasts eclampsia evt evts exaggerated explant extravillous fibronectin floating hes1 labelling maml notch outgrowth overgrowth placental rbpjkappa sirnas trimester trophoblast trophoblasts villi villous
Tagcloud (Intersection) ?