IGFBP3 and ADAM12

  • Number of citations of the paper that reports this interaction (PMID 10849447)
  • 28
  • Data Source:
  • HPRD (in vitro, two hybrid, in vivo)

IGFBP3

ADAM12

Gene Name insulin-like growth factor binding protein 3 ADAM metallopeptidase domain 12
Image No pdb structure No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)
  • Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
  • Visceral fat ( 22589738)
Protein-Protein Interactions 28 interactors: ADAM12 CAV1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 LTBP1 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 RXRA TF 11 interactors: ACTN2 EGF FSTL3 GRB2 IGFBP3 IGFBP5 PACSIN3 PIK3R1 SH3D19 SRC YES1
Entrez ID 3486 8038
HPRD ID 00899 04092
Ensembl ID ENSG00000146674 ENSG00000148848
Uniprot IDs B3KPF0 B3KWK7 P17936 A8K6G4 O43184
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
bioavailability  bioavailable  breast  circulating  clinically  correlation  ectopic  epithelium  expansion  igf1  igfr  inducer  majority  mammary  mitosis  modulated  oestradiol  oestrogen  possibly  postulated  shown  specimens  status  stimulate  stimulating  synergize  upregulate  xenografts 
alpha1  anchoring  balanced  brdu  cct  ccts  cytotrophoblasts  eclampsia  evt  evts  exaggerated  explant  extravillous  fibronectin  floating  hes1  labelling  maml  notch  outgrowth  overgrowth  placental  rbpjkappa  sirnas  trimester  trophoblast  trophoblasts  villi  villous 
Tagcloud (Difference) ?
bioavailability  bioavailable  breast  circulating  clinically  correlation  ectopic  epithelium  expansion  igf1  igfr  inducer  majority  mammary  mitosis  modulated  oestradiol  oestrogen  possibly  postulated  shown  specimens  status  stimulate  stimulating  synergize  upregulate  xenografts 
alpha1  anchoring  balanced  brdu  cct  ccts  cytotrophoblasts  eclampsia  evt  evts  exaggerated  explant  extravillous  fibronectin  floating  hes1  labelling  maml  notch  outgrowth  overgrowth  placental  rbpjkappa  sirnas  trimester  trophoblast  trophoblasts  villi  villous 
Tagcloud (Intersection) ?