ID2 and FRS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ID2	FRS3
Description		inhibitor of DNA binding 2	fibroblast growth factor receptor substrate 3
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GO Annotations	Cellular Component	Euchromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Transcription Corepressor Activity Protein Binding Transmembrane Transporter Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Natural Killer Cell Differentiation Thigmotaxis Leukocyte Differentiation Membranous Septum Morphogenesis Bundle Of His Development Regulation Of Transcription By RNA Polymerase II Heart Development Circadian Rhythm Adult Locomotory Behavior Entrainment Of Circadian Clock Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Regulation Of Lipid Metabolic Process Olfactory Bulb Development Neuron Differentiation B Cell Differentiation Erythrocyte Differentiation Circadian Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Locomotor Rhythm Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macrophage Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Cell Development Cell Maturation Rhythmic Process Peyer's Patch Development Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Cell Morphogenesis Involved In Neuron Differentiation Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation White Fat Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Adipose Tissue Development Mammary Gland Alveolus Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Endodermal Digestive Tract Morphogenesis Cellular Response To Lithium Ion Dopaminergic Neuron Differentiation Cellular Senescence Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Neural Precursor Cell Proliferation	Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		NGF-stimulated transcription	FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 31959851 27182965) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Cognitive decline rate in late mild cognitive impairment ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Mean corpuscular volume ( 28017375) PR interval ( 29127183 30046033 31217584 32439900) Self-reported allergy ( 23817569)	Menarche (age at onset) ( 25231870)
Interacting Genes		56 interacting genes: ADD1 ANAPC1 ANAPC5 ASB4 C22orf39 CDK1 CDK2 DYRK1A DYRK1B ELK1 ELK3 ELK4 ELOC ENKD1 FANCL FNDC11 FRS3 FZR1 GATA4 GFUS HES1 IFI16 KDM1A LRIF1 MAPK1 MAPK3 MAPK8 MSC MSGN1 MYF5 MYF6 MYOD1 MYOG NEDD9 NR0B2 PAX2 PAX5 PAX8 PICK1 PPP1CA PRMT6 RB1 RBL1 RBL2 RBM48 RHOU RIN3 SREBF1 SUV39H1 SUV39H2 TCF12 TCF3 TCF4 TCHP TNS2 UNC119	112 interacting genes: ACTMAP ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 CFAP68 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KCNJ5-AS1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SAXO4 SCNM1 SH2B1 SHANK3 SLAIN1 SLC67A1-AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30
Entrez ID		3398	10817
HPRD ID		02664	06373
Ensembl ID		ENSG00000115738	ENSG00000137218
Uniprot IDs		Q02363 Q53T66	A0A140VJJ7 O43559
PDB IDs		4AYA	2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?		Nucleoplasm Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription E-box Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Fiber Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Skeletal Muscle Fiber Development Skeletal Muscle Cell Differentiation Developmental Process Positive Regulation Of Cell Differentiation Muscle Cell Fate Commitment Regulation Of Lipid Kinase Activity Cellular Response To Starvation RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Keratin Filament Intermediate Filament Protein Binding Outer Ear Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Regulation Of Ossification Cellular Developmental Process Anatomical Structure Morphogenesis Structural Molecule Activity Intermediate Filament Organization Developmental Process Anatomical Structure Formation Involved In Morphogenesis Response To Growth Factor Neurotrophin Receptor Activity Neurotrophin Binding Negative Regulation Of Chondrocyte Proliferation Myelination Intermediate Filament Cytoskeleton Organization Supramolecular Fiber Organization Intermediate Filament-based Process Cell Differentiation Axon Ensheathment Cellular Response To Growth Factor Stimulus
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