ID2 and PAX2

Number of citations of the paper that reports this interaction (PubMedID 11134340)
48

Data Source:
HPRD (in vitro)

		ID2	PAX2
Description		inhibitor of DNA binding 2	paired box 2
Image			No pdb structure
GO Annotations	Cellular Component	Euchromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Chromatin Nucleus Nucleoplasm Microtubule Organizing Center Protein-containing Complex Protein-DNA Complex Centriolar Satellite
	Molecular Function	Transcription Corepressor Activity Protein Binding Transmembrane Transporter Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Natural Killer Cell Differentiation Thigmotaxis Leukocyte Differentiation Membranous Septum Morphogenesis Bundle Of His Development Regulation Of Transcription By RNA Polymerase II Heart Development Circadian Rhythm Adult Locomotory Behavior Entrainment Of Circadian Clock Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Regulation Of Lipid Metabolic Process Olfactory Bulb Development Neuron Differentiation B Cell Differentiation Erythrocyte Differentiation Circadian Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Locomotor Rhythm Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macrophage Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Cell Development Cell Maturation Rhythmic Process Peyer's Patch Development Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Cell Morphogenesis Involved In Neuron Differentiation Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation White Fat Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Adipose Tissue Development Mammary Gland Alveolus Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Endodermal Digestive Tract Morphogenesis Cellular Response To Lithium Ion Dopaminergic Neuron Differentiation Cellular Senescence Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Neural Precursor Cell Proliferation	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Mesonephros Development Neural Tube Closure Optic Cup Morphogenesis Involved In Camera-type Eye Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Retinal Pigment Epithelium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Sensory Organ Development Mesodermal Cell Fate Specification Visual Perception Glial Cell Differentiation Optic Nerve Development Optic Nerve Morphogenesis Optic Nerve Structural Organization Vestibulocochlear Nerve Formation Cell Differentiation Regulation Of Metanephros Size Ureter Maturation Pronephric Field Specification Inner Ear Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development System Development Pronephros Development Brain Morphogenesis Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Mesenchymal To Epithelial Transition Optic Chiasma Development Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Metanephric Mesenchyme Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Mesenchymal Cell Differentiation Nephric Duct Formation Ureter Development Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cochlea Development Cochlea Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Optic Nerve Formation
Pathways		NGF-stimulated transcription	Formation of intermediate mesoderm Formation of the nephric duct Formation of the ureteric bud
Drugs
Diseases			Renal coloboma syndrome (RCS); Papillorenal syndrome
GWAS		Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 31959851 27182965) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Cognitive decline rate in late mild cognitive impairment ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Mean corpuscular volume ( 28017375) PR interval ( 29127183 30046033 31217584 32439900) Self-reported allergy ( 23817569)	Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30679032) Alzheimer's disease ( 20061627) Bitter alcoholic beverage consumption ( 31046077) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Diastolic blood pressure ( 27841878) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889) Systolic blood pressure ( 30578418 28135244 27841878)
Interacting Genes		56 interacting genes: ADD1 ANAPC1 ANAPC5 ASB4 C22orf39 CDK1 CDK2 DYRK1A DYRK1B ELK1 ELK3 ELK4 ELOC ENKD1 FANCL FNDC11 FRS3 FZR1 GATA4 GFUS HES1 IFI16 KDM1A LRIF1 MAPK1 MAPK3 MAPK8 MSC MSGN1 MYF5 MYF6 MYOD1 MYOG NEDD9 NR0B2 PAX2 PAX5 PAX8 PICK1 PPP1CA PRMT6 RB1 RBL1 RBL2 RBM48 RHOU RIN3 SREBF1 SUV39H1 SUV39H2 TCF12 TCF3 TCF4 TCHP TNS2 UNC119	28 interacting genes: BBS1 BBS2 BBS4 BBS7 BEX1 BLID GLCE HNF1B ID2 IL13RA2 KLK6 KLK9 MAPK8 MAPK8IP1 MRC2 NFIC NFIX NSD3 PAXIP1 PRDM14 RASL10B RB1 SFRP2 SNAI1 TRIM25 VHL VPS45 WT1
Entrez ID		3398	5076
HPRD ID		02664	01330
Ensembl ID		ENSG00000115738	ENSG00000075891
Uniprot IDs		Q02363 Q53T66	A0A9L9PXU6 A0A9L9PYK3 Q02962 Q5SZP1
PDB IDs		4AYA
Enriched GO Terms of Interacting Partners?		Nucleoplasm Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription E-box Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Fiber Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Skeletal Muscle Fiber Development Skeletal Muscle Cell Differentiation Developmental Process Positive Regulation Of Cell Differentiation Muscle Cell Fate Commitment Regulation Of Lipid Kinase Activity Cellular Response To Starvation RNA Polymerase II-specific DNA-binding Transcription Factor Binding	BBSome Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Metabolic Process Regulation Of Cilium Movement Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Striatum Development Ciliary Membrane Regulation Of Cilium Beat Frequency Fat Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Brain Morphogenesis Digestive Tract Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Melanosome Transport Positive Regulation Of Biosynthetic Process Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Tube Morphogenesis Negative Regulation Of RNA Metabolic Process Pigment Granule Localization Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Epithelial Tube Morphogenesis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?