ID2 and GATA4

Number of citations of the paper that reports this interaction (PMID 16556596)
2

Data Source:
BioGRID (pull down, pull down)

		ID2	GATA4
Gene Name		inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	GATA binding protein 4
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Cytoskeleton Protein Complex	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Protein Binding Ion Channel Binding Protein Dimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding NFAT Protein Binding Co-SMAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Metanephros Development Natural Killer Cell Differentiation Membranous Septum Morphogenesis Bundle Of His Development Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Regulation Of Lipid Metabolic Process Olfactory Bulb Development Circadian Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Enucleate Erythrocyte Differentiation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Locomotor Rhythm Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Maturation Peyer's Patch Development Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Adipose Tissue Development Mammary Gland Alveolus Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Endodermal Digestive Tract Morphogenesis Positive Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Senescence Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation	In Utero Embryonic Development Gastrulation With Mouth Forming Second Endoderm Formation Heart Looping Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell-cell Signaling Spermatogenesis Endoderm Development Blood Coagulation Male Gonad Development Response To Mechanical Stimulus Negative Regulation Of Autophagy Positive Regulation Vascular Endothelial Growth Factor Production Cardiac Muscle Hypertrophy In Response To Stress Signal Transduction Involved In Regulation Of Gene Expression BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Response To Retinoic Acid Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Response To Drug Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Cardioblast Differentiation Sertoli Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Transdifferentiation SMAD Protein Signal Transduction Atrial Septum Morphogenesis Lung Lobe Formation Intestinal Epithelial Cell Differentiation Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Epithelial Cell Fate Commitment Seminiferous Tubule Development Regulation Of Cardiac Muscle Cell Contraction
Pathways			Peptide hormone metabolism Generic Transcription Pathway Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Factors involved in megakaryocyte development and platelet production Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		IgE levels ( 22075330)	Myopia (pathological) ( 23049088) Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		37 interactors: ADD1 ASB4 CDK2 ELK1 ELK3 ELK4 GATA4 HES1 HSPA5 IFI16 KDM1A LRIF1 MAPK1 MAPK3 MAPK8 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 PAX2 PAX5 PAX8 PPP1CA PRMT6 RB1 RBL1 RBL2 RBM48 SUV39H1 SUV39H2 TCF12 TCF3 TCF4 TSTA3 UNC119	23 interactors: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 SP1 SRF TBX5 ZBTB3 ZFPM2
Entrez ID		3398	2626
HPRD ID		02664	08994
Ensembl ID		ENSG00000115738	ENSG00000136574
Uniprot IDs		Q02363 Q53T66	B3KUF4 B7ZKZ4 P43694
PDB IDs		4AYA	2M9W
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Muscle Structure Development Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Differentiation Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Muscle Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Organ Development Positive Regulation Of Skeletal Muscle Fiber Development Skeletal Muscle Cell Differentiation Cell Fate Commitment Developmental Process Regulation Of Cellular Process Chromatin Modification Tissue Development Skeletal Muscle Tissue Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Development	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Tissue Development RNA Metabolic Process Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression Organ Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Organ Development Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cardiovascular System Development Cardiac Chamber Development Tube Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cardiac Ventricle Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Embryonic Organ Development Muscle Structure Development Biosynthetic Process Regulation Of Gene Expression System Development Regulation Of Nitrogen Compound Metabolic Process Epithelium Development Embryo Development Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Positive Regulation Of Metabolic Process Muscle Tissue Development Anatomical Structure Morphogenesis Blood Vessel Development Anatomical Structure Development Heart Morphogenesis Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Ventricle Morphogenesis
Tagcloud ?		basic bhlh blackfan broadly compensated competed dba declined defect diamond disrupted downregulate e47 enhancing erythroblasts erythroid globin heb helix heterodimer maturation positively precursors progenitors scf scl sequesters stimulates transfusion	6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity
Tagcloud (Difference) ?		basic bhlh blackfan broadly compensated competed dba declined defect diamond disrupted downregulate e47 enhancing erythroblasts erythroid globin heb helix heterodimer maturation positively precursors progenitors scf scl sequesters stimulates transfusion	6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity
Tagcloud (Intersection) ?