ID2 and ELK3

Number of citations of the paper that reports this interaction (PMID 10022839)
29

Data Source:
HPRD (in vitro)

		ID2	ELK3
Gene Name		inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	ELK3, ETS-domain protein (SRF accessory protein 2)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Cytoskeleton Protein Complex	Nucleus Nucleoplasm Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ion Channel Binding Protein Dimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Purine-rich Negative Regulatory Element Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Metanephros Development Natural Killer Cell Differentiation Membranous Septum Morphogenesis Bundle Of His Development Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Regulation Of Lipid Metabolic Process Olfactory Bulb Development Circadian Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Enucleate Erythrocyte Differentiation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Locomotor Rhythm Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Maturation Peyer's Patch Development Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Adipose Tissue Development Mammary Gland Alveolus Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Endodermal Digestive Tract Morphogenesis Positive Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Senescence Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation	Angiogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Cell Differentiation Wound Healing Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS		IgE levels ( 22075330)
Protein-Protein Interactions		37 interactors: ADD1 ASB4 CDK2 ELK1 ELK3 ELK4 GATA4 HES1 HSPA5 IFI16 KDM1A LRIF1 MAPK1 MAPK3 MAPK8 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 PAX2 PAX5 PAX8 PPP1CA PRMT6 RB1 RBL1 RBL2 RBM48 SUV39H1 SUV39H2 TCF12 TCF3 TCF4 TSTA3 UNC119	9 interactors: APP CTBP1 ID2 MAPK14 MAPK8 MAPK9 PIAS1 TCF3 TOP1
Entrez ID		3398	2004
HPRD ID		02664	02593
Ensembl ID		ENSG00000115738
Uniprot IDs		Q02363 Q53T66	P41970
PDB IDs		4AYA
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Muscle Structure Development Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Differentiation Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Muscle Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Organ Development Positive Regulation Of Skeletal Muscle Fiber Development Skeletal Muscle Cell Differentiation Cell Fate Commitment Developmental Process Regulation Of Cellular Process Chromatin Modification Tissue Development Skeletal Muscle Tissue Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Development	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Gene Expression Response To Radiation JUN Phosphorylation Regulation Of Gene Expression Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Metabolic Process Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Toll-like Receptor 4 Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of Muscle Cell Differentiation Response To Molecule Of Bacterial Origin Positive Regulation Of Macromolecule Biosynthetic Process Response To Light Stimulus Innate Immune Response Positive Regulation Of Cellular Metabolic Process Regulation Of Circadian Rhythm Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Differentiation Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Peyer's Patch Development Pattern Recognition Receptor Signaling Pathway Response To External Stimulus Innate Immune Response-activating Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Programmed Cell Death Phosphorylation Activation Of Innate Immune Response Cell Death Death
Tagcloud ?		basic bhlh blackfan broadly compensated competed dba declined defect diamond disrupted downregulate e47 enhancing erythroblasts erythroid globin heb helix heterodimer maturation positively precursors progenitors scf scl sequesters stimulates transfusion	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		basic bhlh blackfan broadly compensated competed dba declined defect diamond disrupted downregulate e47 enhancing erythroblasts erythroid globin heb helix heterodimer maturation positively precursors progenitors scf scl sequesters stimulates transfusion	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?