ID2 and ASB4

Number of citations of the paper that reports this interaction (PubMedID 24586788)
63

Data Source:
BioGRID (enzymatic study)

		ID2	ASB4
Description		inhibitor of DNA binding 2	ankyrin repeat and SOCS box containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Euchromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Transmembrane Transporter Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Natural Killer Cell Differentiation Thigmotaxis Leukocyte Differentiation Membranous Septum Morphogenesis Bundle Of His Development Regulation Of Transcription By RNA Polymerase II Heart Development Circadian Rhythm Adult Locomotory Behavior Entrainment Of Circadian Clock Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Regulation Of Lipid Metabolic Process Olfactory Bulb Development Neuron Differentiation B Cell Differentiation Erythrocyte Differentiation Circadian Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Locomotor Rhythm Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macrophage Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Cell Development Cell Maturation Rhythmic Process Peyer's Patch Development Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Cell Morphogenesis Involved In Neuron Differentiation Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation White Fat Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Adipose Tissue Development Mammary Gland Alveolus Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Endodermal Digestive Tract Morphogenesis Cellular Response To Lithium Ion Dopaminergic Neuron Differentiation Cellular Senescence Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Neural Precursor Cell Proliferation	Protein Ubiquitination Intracellular Signal Transduction Protein Autoubiquitination Positive Regulation Of Vasculogenesis
Pathways		NGF-stimulated transcription	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 31959851 27182965) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Cognitive decline rate in late mild cognitive impairment ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Mean corpuscular volume ( 28017375) PR interval ( 29127183 30046033 31217584 32439900) Self-reported allergy ( 23817569)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Metabolite levels ( 23823483) Middle childhood and early adolescence aggressive behavior ( 26087016)
Interacting Genes		56 interacting genes: ADD1 ANAPC1 ANAPC5 ASB4 C22orf39 CDK1 CDK2 DYRK1A DYRK1B ELK1 ELK3 ELK4 ELOC ENKD1 FANCL FNDC11 FRS3 FZR1 GATA4 GFUS HES1 IFI16 KDM1A LRIF1 MAPK1 MAPK3 MAPK8 MSC MSGN1 MYF5 MYF6 MYOD1 MYOG NEDD9 NR0B2 PAX2 PAX5 PAX8 PICK1 PPP1CA PRMT6 RB1 RBL1 RBL2 RBM48 RHOU RIN3 SREBF1 SUV39H1 SUV39H2 TCF12 TCF3 TCF4 TCHP TNS2 UNC119	3 interacting genes: HIF1AN ID2 UBE2D1
Entrez ID		3398	51666
HPRD ID		02664	05770
Ensembl ID		ENSG00000115738	ENSG00000005981
Uniprot IDs		Q02363 Q53T66	Q9Y574
PDB IDs		4AYA
Enriched GO Terms of Interacting Partners?		Nucleoplasm Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription E-box Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Fiber Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Skeletal Muscle Fiber Development Skeletal Muscle Cell Differentiation Developmental Process Positive Regulation Of Cell Differentiation Muscle Cell Fate Commitment Regulation Of Lipid Kinase Activity Cellular Response To Starvation RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Negative Regulation Of B Cell Differentiation Negative Regulation Of Dopaminergic Neuron Differentiation Transmembrane Transporter Binding Peyer's Patch Development Bundle Of His Development Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Enucleate Erythrocyte Differentiation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Negative Regulation Of Transcription By RNA Polymerase II Endodermal Digestive Tract Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mucosa-associated Lymphoid Tissue Development Negative Regulation Of RNA Biosynthetic Process Thigmotaxis Maintenance Of Centrosome Location Potassium Channel Activator Activity Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Dendritic Branch Extrinsic Component Of Postsynaptic Density Membrane Ankyrin Repeat Binding [protein]-asparagine 3-dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Oxygen Sensor Activity Negative Regulation Of RNA Metabolic Process Potassium Channel Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Locomotor Rhythm Regulation Of Dopaminergic Neuron Differentiation Membranous Septum Morphogenesis Positive Regulation Of Astrocyte Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Vasculogenesis Ventricular Cardiac Muscle Tissue Development Negative Regulation Of Oligodendrocyte Differentiation Response To Lithium Ion Positive Regulation Of Macrophage Differentiation Embryonic Digestive Tract Morphogenesis Mammary Gland Epithelial Cell Differentiation Cellular Response To Lithium Ion Mammary Gland Alveolus Development Mammary Gland Epithelial Cell Proliferation White Fat Cell Differentiation Positive Regulation Of Protein Polyubiquitination Regulation Of Golgi Organization Regulation Of Vasculogenesis Natural Killer Cell Differentiation Cell Morphogenesis Involved In Neuron Differentiation
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