HMGB3 and TERF2IP

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		HMGB3	TERF2IP
Gene Name		high mobility group box 3	telomeric repeat binding factor 2, interacting protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Chromosome	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mre11 Complex
	Molecular Function	Chromatin Binding Double-stranded DNA Binding DNA Binding, Bending Poly(A) RNA Binding	Protein Binding Telomeric DNA Binding
	Biological Process	DNA Recombination Chromatin Remodeling Regulation Of Transcription, DNA-templated Multicellular Organismal Development Negative Regulation Of B Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation	Telomere Maintenance Transcription, DNA-templated Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: HMGA1 SDCBP TERF2IP	125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPKOW HAAO HAGH HDGFRP3 HIST1H1A HIST1H2AL HIST1H4B HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414
Entrez ID		3149	54386
HPRD ID		02181	05452
Ensembl ID		ENSG00000029993	ENSG00000166848
Uniprot IDs		O15347	Q9NYB0
PDB IDs		2EQZ 2YQI	1FEX 3K6G
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Oncogene-induced Cell Senescence Senescence-associated Heterochromatin Focus Assembly DNA Replication Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cellular Senescence Protection From Non-homologous End Joining At Telomere Regulation Of Extracellular Vesicular Exosome Assembly Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Chromatin Silencing Establishment Of Integrated Proviral Latency Positive Regulation Of Cell Aging Establishment Of Viral Latency Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Heterochromatin Assembly Substrate-dependent Cell Migration, Cell Extension Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Unwinding Involved In DNA Replication Nucleosome Disassembly Heterochromatin Organization Positive Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Maintenance Organelle Organization RNA-dependent DNA Replication Regulation Of Gene Silencing Negative Regulation Of DNA Recombination Regulation Of Cellular Senescence Positive Regulation Of Organelle Assembly Regulation Of Double-strand Break Repair Positive Regulation Of Intracellular Signal Transduction Protein Localization To Chromosome Cellular Senescence Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomere Lengthening Regulation Of Organelle Organization Substrate-dependent Cell Migration Chromosome Organization DNA Metabolic Process Positive Regulation Of Exocytosis Regulation Of DNA Repair Base-excision Repair Positive Regulation Of Signal Transduction Regulation Of DNA Recombination Cell Aging Cellular Protein Localization Telomere Maintenance	Chromosome Organization Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Organelle Organization Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process DNA Conformation Change Chromatin Modification Cell Cycle Cellular Response To Stress DNA Metabolic Process Cellular Response To DNA Damage Stimulus Sequestering Of Actin Monomers DNA Recombination Telomere Maintenance Via Telomere Lengthening Catabolic Process DNA Duplex Unwinding Cellular Aldehyde Metabolic Process Cellular Hyperosmotic Salinity Response DNA Geometric Change DNA Replication Energy Reserve Metabolic Process Nucleosome Organization Organophosphate Catabolic Process Response To Stress Chromatin Assembly Or Disassembly Deoxyribose Phosphate Catabolic Process Cellular Localization Cellular Metabolic Process Protein Localization To Nucleus Glycogen Metabolic Process Nucleocytoplasmic Transport Chromatin Remodeling Base-excision Repair Cellular Response To X-ray Nuclear Transport Aromatic Compound Catabolic Process Nucleosome Assembly Deoxyribonucleotide Catabolic Process DNA Strand Elongation Involved In DNA Replication Small Molecule Metabolic Process DNA Strand Elongation Biosynthetic Process Chromatin Assembly Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Transport Energy Derivation By Oxidation Of Organic Compounds
Tagcloud ?		5p calr cd34 cd41 cdc42 downregulation dysregulation eg fgr gathering hyperplasia integrative jarid2 lcn2 megakaryocyte microrna mirna mk mks mpl myelofibrosis neoplasm nr4a3 olfm4 pathophysiology pmf precursors strongest unveiled	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Difference) ?		5p calr cd34 cd41 cdc42 downregulation dysregulation eg fgr gathering hyperplasia integrative jarid2 lcn2 megakaryocyte microrna mirna mk mks mpl myelofibrosis neoplasm nr4a3 olfm4 pathophysiology pmf precursors strongest unveiled	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Intersection) ?