HMGB3 and HMGA1

Number of citations of the paper that reports this interaction (PMID 18850631)
2

Data Source:
BioGRID (far western blotting)

		HMGB3	HMGA1
Gene Name		high mobility group box 3	high mobility group AT-hook 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Chromosome	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Focal Adhesion Senescence-associated Heterochromatin Focus
	Molecular Function	Chromatin Binding Double-stranded DNA Binding DNA Binding, Bending Poly(A) RNA Binding	DNA Binding AT DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	DNA Recombination Chromatin Remodeling Regulation Of Transcription, DNA-templated Multicellular Organismal Development Negative Regulation Of B Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation	DNA Catabolic Process, Endonucleolytic DNA Unwinding Involved In DNA Replication Base-excision Repair Nucleosome Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Negative Regulation Of Cell Proliferation Response To Virus Viral Process Negative Regulation Of Chromatin Silencing Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Establishment Of Integrated Proviral Latency Oncogene-induced Cell Senescence Positive Regulation Of Cellular Senescence
Pathways			DNA Damage/Telomere Stress Induced Senescence Vpr-mediated nuclear import of PICs HIV Infection Cellular Senescence Host Interactions of HIV factors Integration of provirus Interactions of Vpr with host cellular proteins Early Phase of HIV Life Cycle Autointegration results in viral DNA circles HIV Life Cycle Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2-LTR circle formation Integration of viral DNA into host genomic DNA APOBEC3G mediated resistance to HIV-1 infection
Drugs
Diseases
GWAS			Body mass index ( 20935630) Height ( 21998595 20881960 19396169 19343178 19893584 23563607 18391951 20397748 20189936)
Protein-Protein Interactions		3 interactors: HMGA1 SDCBP TERF2IP	60 interactors: ANXA1 ANXA2 APEX1 ATF2 CDK1 CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EWSR1 GTF2F2 HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HSPA1A IRF1 JUN KAT2B METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PARP1 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RCC1 RN7SK RNF4 RXRA SP1 SRF SSB SUFU SYNCRIP UPF2
Entrez ID		3149	3159
HPRD ID		02181	02829
Ensembl ID		ENSG00000029993	ENSG00000137309
Uniprot IDs		O15347	P17096 Q5T6U8
PDB IDs		2EQZ 2YQI	2EZD 2EZE 2EZF 2EZG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Oncogene-induced Cell Senescence Senescence-associated Heterochromatin Focus Assembly DNA Replication Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cellular Senescence Protection From Non-homologous End Joining At Telomere Regulation Of Extracellular Vesicular Exosome Assembly Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Chromatin Silencing Establishment Of Integrated Proviral Latency Positive Regulation Of Cell Aging Establishment Of Viral Latency Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Heterochromatin Assembly Substrate-dependent Cell Migration, Cell Extension Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Unwinding Involved In DNA Replication Nucleosome Disassembly Heterochromatin Organization Positive Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Maintenance Organelle Organization RNA-dependent DNA Replication Regulation Of Gene Silencing Negative Regulation Of DNA Recombination Regulation Of Cellular Senescence Positive Regulation Of Organelle Assembly Regulation Of Double-strand Break Repair Positive Regulation Of Intracellular Signal Transduction Protein Localization To Chromosome Cellular Senescence Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomere Lengthening Regulation Of Organelle Organization Substrate-dependent Cell Migration Chromosome Organization DNA Metabolic Process Positive Regulation Of Exocytosis Regulation Of DNA Repair Base-excision Repair Positive Regulation Of Signal Transduction Regulation Of DNA Recombination Cell Aging Cellular Protein Localization Telomere Maintenance	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Gene Expression Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Gene Expression RNA Splicing Biosynthetic Process Negative Regulation Of Transcription, DNA-templated RNA Processing Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Regulation Of Cell Cycle Viral Process Cell Differentiation Metabolic Process DNA-templated Transcription, Initiation Cellular Response To Organic Substance Developmental Process Regulation Of Cell Differentiation
Tagcloud ?		5p calr cd34 cd41 cdc42 downregulation dysregulation eg fgr gathering hyperplasia integrative jarid2 lcn2 megakaryocyte microrna mirna mk mks mpl myelofibrosis neoplasm nr4a3 olfm4 pathophysiology pmf precursors strongest unveiled	arresting attribute augments bcl2 concomitantly e2 e6 evidences g0 galactosidase hmgb1 hpv16 htert kb linking mechanistic messaging papilloma re senescence senescent sensitizes shifted siha survivin sustaining tendency tnf tumorigenesis
Tagcloud (Difference) ?		5p calr cd34 cd41 cdc42 downregulation dysregulation eg fgr gathering hyperplasia integrative jarid2 lcn2 megakaryocyte microrna mirna mk mks mpl myelofibrosis neoplasm nr4a3 olfm4 pathophysiology pmf precursors strongest unveiled	arresting attribute augments bcl2 concomitantly e2 e6 evidences g0 galactosidase hmgb1 hpv16 htert kb linking mechanistic messaging papilloma re senescence senescent sensitizes shifted siha survivin sustaining tendency tnf tumorigenesis
Tagcloud (Intersection) ?