HMGB3 and RPRD1B

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		HMGB3	RPRD1B
Name		high mobility group box 3	regulation of nuclear pre-mRNA domain containing 1B
Structure
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm	Nucleus Nucleoplasm Transcription Preinitiation Complex
	Molecular Function	Four-way Junction DNA Binding DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding DNA Binding, Bending	RNA Polymerase II Complex Binding Protein Binding Identical Protein Binding RNA Polymerase II C-terminal Domain Binding
	Biological Process	Immune System Process DNA Recombination DNA Geometric Change Innate Immune Response Negative Regulation Of B Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation	RNA Polymerase II Promoter Clearance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Process MRNA 3'-end Processing Positive Regulation Of Transcription By RNA Polymerase II
Pathways		None	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		9 interacting genes: CEBPA HMGA1 MEOX1 MEOX2 PAX5 PAX6 RPRD1B SDCBP TERF2IP	22 interacting genes: BIN3 CDCA8 DDIT4L EIF4ENIF1 HMG20A HMGB3 HOXC4 NUTF2 PFDN6 PIP4K2B PSMB1 RASSF3 SPG21 STAT3 STEEP1 TERF2 TNPO2 TUBGCP4 UBE2I VAX1 VPS37C WEE2-AS1
Entrez ID		3149	58490
HPRD ID		02181	08513
Ensembl ID		ENSG00000029993	ENSG00000101413
Uniprot IDs		O15347	Q9NQG5
PDB IDs		2EQZ 2YQI	4FLA 4FU3 4HFG 4NAD 4Q94 4Q96 9B9L
GO Terms Enriched among Interactors		HMG Box Domain Binding Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Somite Specification Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Segment Specification Somite Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Chromatin Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleus Nucleic Acid Metabolic Process DNA Binding Transcription Coregulator Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Embryonic Pattern Specification RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Interleukin-5 Receptor Complex Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Nucleoplasm Cerebral Cortex Development	Import Into Nucleus Protein Import Into Nucleus Nuclear Transport Nucleocytoplasmic Transport Cellular Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Intracellular Transport Protein Localization To Nucleus Protein Localization To Organelle Membrane Organization Negative Regulation Of Cell Differentiation Nuclear Import Signal Receptor Activity Establishment Of Localization In Cell Nuclear Export Negative Regulation Of Developmental Process Astrocyte Differentiation Intracellular Protein Localization Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair SUMO Conjugating Enzyme Activity Actin Cortical Patch Localization Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA