HLA-B and LCOR

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HLA-B	LCOR
Description		major histocompatibility complex, class I, B	ligand dependent nuclear receptor corepressor
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm
	Molecular Function	Signaling Receptor Binding Protein Binding Peptide Antigen Binding TAP Binding Protein-folding Chaperone Binding	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Anergy Defense Response Immune Response Detection Of Bacterium Antigen Processing And Presentation Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Protection From Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Regulation Of Dendritic Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Abacavir N-Formylmethionine Coccidioides immitis spherule
Diseases
GWAS		A body shape index ( 34021172) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Acute anterior uveitis in ankylosing spondylitis ( 25200001 32492107) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Ankylosing spondylitis ( 21743469 30946743) Anti-thyroid drug induced agranulocytosis ( 27157822) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Asthma ( 30929738 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433 31619474) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Behcet's disease ( 24326010 27548383) Beta-2 microglubulin plasma levels ( 23417110) Body fat percentage variance ( 31453325) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Cardiometabolic and hematological traits ( 27668658) CD4:CD8 lymphocyte ratio ( 20045101) CD8-positive T-lymphocyte count ( 20045101) Cervical cancer ( 23482656 28806749) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208) Change in intraocular pressure in response to steroid treatment (triamcinolone acetonide) ( 25813999) Chickenpox ( 28928442) Clozapine-induced agranulocytosis ( 25187353) Cold sores ( 28928442) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Crohn's disease ( 26891255) Diastolic blood pressure ( 25249183) Diffuse large B cell lymphoma ( 25261932) Drug-induced liver injury (flucloxacillin) ( 19483685 30661239) Eosinophil count ( 29403010) Eosinophil percentage of white cells ( 27863252) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Estimated glomerular filtration rate in diabetes ( 31451708) Frontal fibrosing alopecia ( 30850646) Gastroesophageal reflux disease ( 31527586) Giant cell arteritis ( 28041642) Graves' disease ( 21841780) HDL cholesterol levels ( 32203549) Height ( 19343178 23563607 31562340) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166 21051598) HIV-1 susceptibility ( 23935489) HIV-1 viral setpoint ( 20205591 26039976) Hypothyroidism ( 22493691) IgA nephropathy ( 26028593) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels ( 32203549) Leukoderma in response to rhododendrol ( 32558222) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Marginal zone lymphoma ( 25569183) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Medication use (salicylic acid and derivatives) ( 31015401) Metabolic syndrome ( 31589552) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 19525953 22190364) Myositis ( 26291516) Nasal polyps ( 30643255) Nasopharyngeal carcinoma ( 20512145) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 29403010) Neutrophil percentage of white cells ( 32888494) Nevirapine-induced hypersensitivity in HIV ( 28062682) Non-albumin protein levels ( 29403010) Penicillin allergy ( 32888428) Peripheral artery disease ( 31285632) Plantar warts ( 28928442) Platelet count ( 22139419 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pneumonia ( 28928442) Pre-treatment viral load in HIV-1 infection ( 31219150) Primary sclerosing cholangitis ( 23603763) Proliferative diabetic retinopathy ( 31482010) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Red blood cell count ( 32888494) Rheumatic heart disease ( 32488134) Rheumatoid arthritis (ACPA-negative) ( 24532677) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Serum albumin levels ( 29403010) Setpoint viral load in HIV-1 infection ( 26553974) Severe aplastic anemia ( 32004448) Shingles ( 25297839 28928442 30298529) Small cell lung carcinoma ( 28604730) Strep throat ( 28928442) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 26606652 28714469) Systolic blood pressure ( 25249183) Takayasu arteritis ( 23830517 25604533 30498034 33308445) Tonsillectomy ( 28928442) Tonsillitis ( 30037793) Trichloroethylene-induced hypersensitivity syndrome ( 26190474) Triglyceride levels ( 32203549 33339817) Tuberculosis ( 28928442) Type 2 diabetes ( 25102180) Ulcerative colitis ( 28067908) Visceral adipose tissue adjusted for BMI ( 22589738) Vitiligo ( 20526339) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 21738480 25096241 29403010 32888494) White blood cell count (basophil) ( 27863252) White matter integrity (mean diffusivity) ( 32358547)	Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)
Interacting Genes		17 interacting genes: ARHGEF4 ATF7IP B2M CD8A CSF1 KIR3DL1 KIR3DS1 KLRD1 LCOR LILRB1 LILRB2 MAGEA1 SRC STAT1 TRA TRB TRIB3	144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE
Entrez ID		3106	84458
HPRD ID		00828	07609
Ensembl ID		ENSG00000234745	ENSG00000196233
Uniprot IDs		D9J307 E5FQ95 P01889	Q96JN0
PDB IDs		1A1M 1A1N 1A1O 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1CG9 1E27 1E28 1HSA 1JGD 1JGE 1K5N 1M05 1M6O 1MI5 1N2R 1OF2 1OGT 1SYS 1SYV 1UXS 1UXW 1W0V 1W0W 1XH3 1XR8 1XR9 1ZHK 1ZHL 1ZSD 2A83 2AK4 2AXF 2AXG 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2H6P 2HJL 2NW3 2NX5 2RFX 2YPK 2YPL 3B3I 3B6S 3BP4 3BP7 3BW9 3BWA 3C9N 3CZF 3D18 3DTX 3DX6 3DX7 3DX8 3DXA 3FFC 3HCV 3KPL 3KPM 3KPN 3KPO 3KPP 3KPQ 3KPR 3KPS 3KWW 3KXF 3L3D 3L3G 3L3I 3L3J 3L3K 3LKN 3LKO 3LKP 3LKQ 3LKR 3LKS 3LN4 3LN5 3LV3 3MV7 3MV8 3MV9 3SJV 3SKM 3SKO 3SPV 3UPR 3VCL 3VFS 3VFT 3VFU 3VFV 3VFW 3VH8 3VRI 3VRJ 3W39 3WUW 3X11 3X12 3X13 3X14 4G8G 4G8I 4G9D 4G9F 4JQV 4JQX 4LCY 4LNR 4MJI 4O2C 4O2E 4O2F 4PR5 4PRN 4QRP 4QRQ 4QRR 4QRS 4QRT 4QRU 4U1H 4U1I 4U1J 4U1K 4U1L 4U1M 4U1N 4U1S 4XXC 5B38 5B39 5DEF 5DEG 5EO0 5EO1 5IB1 5IB2 5IB3 5IB4 5IB5 5IEH 5IEK 5IM7 5INC 5IND 5T6W 5T6X 5T6Y 5T6Z 5T70 5TXS 5U98 5V5L 5V5M 5VUD 5VUE 5VUF 5VWD 5VWF 5VWH 5VWJ 5VZ5 5WMN 5WMO 5WMP 5WMQ 5WMR 5XOS 5XOT 6AT5 6AVF 6AVG 6BJ2 6BJ3 6BJ8 6BXP 6BXQ 6D29 6D2B 6D2R 6D2T 6MT3 6MT4 6MT5 6MT6 6MTL 6MTM 6P23 6P27 6P2C 6P2F 6P2S 6PYJ 6PYL 6PYV 6PYW 6PZ5 6UJ7 6UJ8 6UJ9 6UZP 6UZQ 6UZS 6VMX 7LFZ 7LG0 7LGD 7LGT 7RZD 7RZJ 7S79 7S7D 7S7E 7S7F 7S8A 7S8E 7S8F 7XF3 8TUB 8TUH	2COB 6V3X 6V3Y
Enriched GO Terms of Interacting Partners?		Immune Effector Process Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Adaptive Immune Response Immune Response T Cell Mediated Immunity Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune System Process T Cell Mediated Cytotoxicity Leukocyte Mediated Cytotoxicity MHC Class I Protein Binding T Cell Receptor Complex HLA-B Specific Inhibitory MHC Class I Receptor Activity Detection Of Tumor Cell MHC Class Ib Protein Complex Binding Regulation Of Immune Response Plasma Membrane Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response-regulating Cell Surface Receptor Signaling Pathway MHC Class I Receptor Activity Fc Receptor Mediated Inhibitory Signaling Pathway Leukocyte Activation Regulation Of T Cell Mediated Cytotoxicity Cellular Response To Oxygen-containing Compound MHC Class Ib Protein Binding Response To External Biotic Stimulus MHC Class I Protein Complex Binding Alpha-beta T Cell Receptor Complex Immune Response To Tumor Cell Inhibitory MHC Class I Receptor Activity Cell Activation Positive Regulation Of Immune System Process Cell Killing Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of T Cell Mediated Cytotoxicity Interleukin-10-mediated Signaling Pathway Regulation Of Hemopoiesis Response To Other Organism Immune Response-inhibiting Signal Transduction Regulation Of Myeloid Cell Differentiation Cellular Response To Lipid Amyloid-beta Binding Positive Regulation Of Cell Adhesion Signal Transduction Positive Regulation Of T Cell Activation Regulation Of Lymphocyte Activation Regulation Of Leukocyte Mediated Cytotoxicity	Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding
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