HLA-B and ARHGEF4

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		HLA-B	ARHGEF4
Gene Name		major histocompatibility complex, class I, B	Rho guanine nucleotide exchange factor (GEF) 4
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Cytosol Ruffle Membrane
	Molecular Function	Receptor Binding Peptide Antigen Binding TAP Binding Chaperone Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding Rac Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Anergy Defense Response Immune Response Viral Process Detection Of Bacterium Cytokine-mediated Signaling Pathway Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Dendritic Cell Differentiation	Small GTPase Mediated Signal Transduction Lamellipodium Assembly Positive Regulation Of Rac GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Beta-2 microglubulin plasma levels ( 23417110) CD4:CD8 lymphocyte ratio ( 20045101) Cervical cancer ( 23482656) Drug-induced liver injury (flucloxacillin) ( 19483685) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Graves' disease ( 21841780) Height ( 19343178 23563607) HIV-1 control ( 20205591 21051598 20041166) Hypothyroidism ( 22493691) Multiple sclerosis ( 22190364 19525953) Nasopharyngeal carcinoma ( 20512145) Platelet counts ( 22139419) Visceral adipose tissue adjusted for BMI ( 22589738) Vitiligo ( 20526339) White blood cell count ( 21738480)
Protein-Protein Interactions		16 interactors: ARHGEF4 ATF7IP B2M CD8A CSF1 KIR3DL1 KIR3DS1 KLRD1 LILRB1 LILRB2 MAGEA1 SRC STAT1 TRA TRB TRIB3	5 interactors: APC HLA-B KHDRBS1 RAC1 RHOA
Entrez ID		3106	50649
HPRD ID		00828	05559
Ensembl ID		ENSG00000234745	ENSG00000136002
Uniprot IDs		E5FQ95 P01889 P30466 S6AU73	Q9NR80 Q9NTG0
PDB IDs		3VCL 4JQV	2DX1 2PZ1 3NMX 3NMZ
Enriched GO Terms of Interacting Partners?		Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Immune System Process Innate Immune Response Leukocyte Differentiation Response To Molecule Of Bacterial Origin Cell Activation Cellular Response To Lipopolysaccharide Response To Other Organism Fc Receptor Mediated Inhibitory Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Response To Biotic Stimulus Response To Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Response To Bacterium Immune Response-inhibiting Signal Transduction Leukocyte Activation Single Organismal Cell-cell Adhesion Regulation Of Dendritic Cell Differentiation Signal Transduction Cell Surface Receptor Signaling Pathway Response To Virus Hemopoiesis Signaling Response To Lipopolysaccharide Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune System Development Cellular Response To Organic Substance Positive Regulation Of Cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Lymphocyte Activation Cellular Response To Lipid Defense Response To Virus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Immune System Process Response To Stimulus Immune Response-regulating Signaling Pathway Tissue Homeostasis Negative Regulation Of Cell Adhesion Viral Process Positive Regulation Of T Cell Activation Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion	Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Signal Transduction Positive Regulation Of Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Stress Fiber Assembly Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Regulation Of Cell Differentiation Apical Junction Assembly Viral Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Cytokinesis Neuron Projection Morphogenesis Positive Regulation Of Nucleocytoplasmic Transport Mitotic Cell Cycle Process Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Cell-cell Junction Assembly Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cell Division Mitotic Cell Cycle Cell Cycle Arrest Neuron Projection Development Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of RNA Export From Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cell Migration Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Complex Assembly Cell Motility Regulation Of Organelle Organization Signal Transduction
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