HLA-B and CD8A

Number of citations of the paper that reports this interaction (PMID 10809759)
23

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		HLA-B	CD8A
Gene Name		major histocompatibility complex, class I, B	CD8a molecule
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane T Cell Receptor Complex
	Molecular Function	Receptor Binding Peptide Antigen Binding TAP Binding Chaperone Binding	Protein Binding Coreceptor Activity Protein Kinase Binding MHC Class I Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Anergy Defense Response Immune Response Viral Process Detection Of Bacterium Cytokine-mediated Signaling Pathway Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Dendritic Cell Differentiation	T Cell Mediated Immunity Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling Defense Response To Virus
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Beta-2 microglubulin plasma levels ( 23417110) CD4:CD8 lymphocyte ratio ( 20045101) Cervical cancer ( 23482656) Drug-induced liver injury (flucloxacillin) ( 19483685) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Graves' disease ( 21841780) Height ( 19343178 23563607) HIV-1 control ( 20205591 21051598 20041166) Hypothyroidism ( 22493691) Multiple sclerosis ( 22190364 19525953) Nasopharyngeal carcinoma ( 20512145) Platelet counts ( 22139419) Visceral adipose tissue adjusted for BMI ( 22589738) Vitiligo ( 20526339) White blood cell count ( 21738480)
Protein-Protein Interactions		16 interactors: ARHGEF4 ATF7IP B2M CD8A CSF1 KIR3DL1 KIR3DS1 KLRD1 LILRB1 LILRB2 MAGEA1 SRC STAT1 TRA TRB TRIB3	17 interactors: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1
Entrez ID		3106	925
HPRD ID		00828	01737
Ensembl ID		ENSG00000234745	ENSG00000153563
Uniprot IDs		E5FQ95 P01889 P30466 S6AU73	P01732 Q6ZVS2 Q8TAW8
PDB IDs		3VCL 4JQV	1AKJ 1CD8 1Q69 2HP4 3QZW
Enriched GO Terms of Interacting Partners?		Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Immune System Process Innate Immune Response Leukocyte Differentiation Response To Molecule Of Bacterial Origin Cell Activation Cellular Response To Lipopolysaccharide Response To Other Organism Fc Receptor Mediated Inhibitory Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Response To Biotic Stimulus Response To Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Response To Bacterium Immune Response-inhibiting Signal Transduction Leukocyte Activation Single Organismal Cell-cell Adhesion Regulation Of Dendritic Cell Differentiation Signal Transduction Cell Surface Receptor Signaling Pathway Response To Virus Hemopoiesis Signaling Response To Lipopolysaccharide Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune System Development Cellular Response To Organic Substance Positive Regulation Of Cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Lymphocyte Activation Cellular Response To Lipid Defense Response To Virus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Immune System Process Response To Stimulus Immune Response-regulating Signaling Pathway Tissue Homeostasis Negative Regulation Of Cell Adhesion Viral Process Positive Regulation Of T Cell Activation Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune Response Positive Regulation Of Adaptive Immune Response Immune System Process Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Activation Innate Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Lymphocyte Activation Defense Response Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Cell-cell Adhesion Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Regulation Of Cell Activation Response To Type I Interferon Positive Regulation Of Cell Activation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Defense Response To Virus By Virus Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Processing And Presentation Cell Activation Negative Regulation Of Immune Response Leukocyte Activation T Cell Aggregation T Cell Activation
Tagcloud ?			anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
Tagcloud (Difference) ?			anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
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