CDSN and HPCAL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDSN	HPCAL4
Description		corneodesmosin	hippocalcin like 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Plasma Membrane Cell-cell Junction Desmosome
	Molecular Function	Protein Homodimerization Activity	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Corneocyte Desquamation Cell Adhesion Epidermis Development Keratinocyte Differentiation Skin Morphogenesis Cell-cell Adhesion Negative Regulation Of Cornification Amyloid Fibril Formation	Central Nervous System Development Response To Heat Regulation Of Signal Transduction
Pathways		Formation of the cornified envelope
Drugs
Diseases		Hypotrichosis simplex of scalp
GWAS		Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Hematology traits ( 23263863) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Multiple myeloma ( 23955597) Schizophrenia ( 28991256) Systemic mastocytosis ( 32752121) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) White blood cell count ( 21738480 20139978)	Bone mineral density (Ward's triangle area) ( 27397699)
Interacting Genes		37 interacting genes: ASPH ATXN1L BAG6 BANP CCHCR1 CEP55 CSTF2 CSTF2T CTNNA3 DESI1 EIF3F ENKD1 EXOC8 FAM9B HGS HPCAL4 ITPRIPL1 KCNIP3 KLK7 LCN2 NCS1 NELFCD PARVG PLVAP PRKAB2 SGTA SGTB SMARCD1 TGM7 TRIM69 TSGA10 UBQLN1 UBQLN2 UBQLN4 UCHL5 VSNL1 ZDHHC17	16 interacting genes: ANKRD33 AQP4 CDSN CEACAM6 DTX2 F3 FAM131C LITAF MSRA SCMH1 SPRED1 TEX13B TRPM5 TSC22D3 TTC12 UBE3A
Entrez ID		1041	51440
HPRD ID		03998	17113
Ensembl ID		ENSG00000204539	ENSG00000116983
Uniprot IDs		Q15517	B4DGW9 Q9UM19
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding TRC Complex Protein Targeting To ER Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Endoplasmic Reticulum ERAD Pathway Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Centriole Protein Targeting To Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane MRNA Cleavage And Polyadenylation Specificity Factor Complex Molecular Adaptor Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasome Binding Autophagosome Proteolysis Regulation Of Macroautophagy Localization Within Membrane Protein Targeting Protein Binding Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Establishment Of Protein Localization Cytoplasm
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