CDSN and PARVG

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDSN	PARVG
Description		corneodesmosin	parvin gamma
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Plasma Membrane Cell-cell Junction Desmosome	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Anchoring Junction
	Molecular Function	Protein Homodimerization Activity	Actin Binding Protein Binding
	Biological Process	Corneocyte Desquamation Cell Adhesion Epidermis Development Keratinocyte Differentiation Skin Morphogenesis Cell-cell Adhesion Negative Regulation Of Cornification Amyloid Fibril Formation	Cell Adhesion Cell-matrix Adhesion Cell Projection Assembly Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape
Pathways		Formation of the cornified envelope
Drugs
Diseases		Hypotrichosis simplex of scalp
GWAS		Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Hematology traits ( 23263863) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Multiple myeloma ( 23955597) Schizophrenia ( 28991256) Systemic mastocytosis ( 32752121) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) White blood cell count ( 21738480 20139978)	Fasting glucose ( 33381925) Metabolite levels ( 23823483) Survival in colon cancer ( 25866641)
Interacting Genes		37 interacting genes: ASPH ATXN1L BAG6 BANP CCHCR1 CEP55 CSTF2 CSTF2T CTNNA3 DESI1 EIF3F ENKD1 EXOC8 FAM9B HGS HPCAL4 ITPRIPL1 KCNIP3 KLK7 LCN2 NCS1 NELFCD PARVG PLVAP PRKAB2 SGTA SGTB SMARCD1 TGM7 TRIM69 TSGA10 UBQLN1 UBQLN2 UBQLN4 UCHL5 VSNL1 ZDHHC17	33 interacting genes: ALX4 ANTKMT APP CDHR3 CDSN CFAP53 CSF3 DDIT4L FOSL1 GADD45A HOMEZ ILK KCTD7 KLHL32 LHX3 LNX2 MEOX1 MEOX2 NBPF22P NBPF6 NDEL1 PDLIM7 POLR2G POU6F2 REL SERTAD2 TLE5 TRIB2 TRIM54 TSGA10IP USHBP1 ZNF426 ZNF677
Entrez ID		1041	64098
HPRD ID		03998	16285
Ensembl ID		ENSG00000204539	ENSG00000138964
Uniprot IDs		Q15517	Q9HBI0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding TRC Complex Protein Targeting To ER Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Endoplasmic Reticulum ERAD Pathway Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Centriole Protein Targeting To Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane MRNA Cleavage And Polyadenylation Specificity Factor Complex Molecular Adaptor Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasome Binding Autophagosome Proteolysis Regulation Of Macroautophagy Localization Within Membrane Protein Targeting Protein Binding Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Establishment Of Protein Localization Cytoplasm	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Somite Specification DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin HMG Box Domain Binding Positive Regulation Of RNA Metabolic Process Segment Specification Somite Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process
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