CDSN and KLK7

Number of citations of the paper that reports this interaction (PMID 15140227)
59

Data Source:
BioGRID (enzymatic study)

		CDSN	KLK7
Gene Name		corneodesmosin	kallikrein-related peptidase 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cornified Envelope Cell-cell Junction Desmosome Extracellular Vesicular Exosome	Extracellular Region Epidermal Lamellar Body
	Molecular Function	Protein Homodimerization Activity	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Cell Adhesion Epidermis Development Single Organismal Cell-cell Adhesion Keratinocyte Differentiation Skin Morphogenesis	Proteolysis Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways			Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Hematology traits ( 23263863) HIV-1 control ( 20041166) White blood cell count ( 20139978 21738480)
Protein-Protein Interactions		5 interactors: CEP55 KLK7 UBQLN4 UCHL5 ZDHHC17	2 interactors: APP CDSN
Entrez ID		1041	5650
HPRD ID		03998	05115
Ensembl ID		ENSG00000204539	ENSG00000169035
Uniprot IDs		Q15517	B4DHX9 P49862
PDB IDs			2QXG 2QXH 2QXI 2QXJ 3BSQ
Enriched GO Terms of Interacting Partners?			Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Adhesion Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Skin Morphogenesis Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Keratinocyte Differentiation Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth RNA 3'-end Processing Cholesterol Metabolic Process Adult Locomotory Behavior
Tagcloud ?		ageing alleviates collagen corneodesmosin corneodesmosomal desmocollin desmoglein desmosomes desquamation diphosphate dsc1 dsg1 equivalents fdp fibres fluxes fructose glycolytic kallikrein keratinocytes klk klk7 metabolite nheks peeling proteases serca2 ses ultraviolet	chymotrypsin corneodesmosomes corneum desmocollin desmoglein detached dsc1 dsg1 filaggrin gels kallikreins kazal klk5 knockdowns lekti lympho netherton omim organotypic parakeratotic populated recapitulates scce scte spink5 stratum therapeutically thicker transfecting
Tagcloud (Difference) ?		ageing alleviates collagen corneodesmosin corneodesmosomal desmosomes desquamation diphosphate equivalents fdp fibres fluxes fructose glycolytic kallikrein keratinocytes klk metabolite nheks peeling proteases serca2 ses ultraviolet	chymotrypsin corneodesmosomes corneum detached filaggrin gels kallikreins kazal klk5 knockdowns lekti lympho netherton omim organotypic parakeratotic populated recapitulates scce scte spink5 stratum therapeutically thicker transfecting
Tagcloud (Intersection) ?		desmocollin desmoglein dsc1 dsg1 klk7