CDSN and ITPRIPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDSN	ITPRIPL1
Description		corneodesmosin	ITPRIP like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Plasma Membrane Cell-cell Junction Desmosome	Plasma Membrane Membrane
	Molecular Function	Protein Homodimerization Activity	Protein Binding Receptor Ligand Activity
	Biological Process	Corneocyte Desquamation Cell Adhesion Epidermis Development Keratinocyte Differentiation Skin Morphogenesis Cell-cell Adhesion Negative Regulation Of Cornification Amyloid Fibril Formation	Signal Transduction Negative Regulation Of Signal Transduction T Cell Differentiation T Cell Activation Positive Regulation Of MAPK Cascade T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Calcium Ion Import
Pathways		Formation of the cornified envelope
Drugs
Diseases		Hypotrichosis simplex of scalp
GWAS		Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Hematology traits ( 23263863) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Multiple myeloma ( 23955597) Schizophrenia ( 28991256) Systemic mastocytosis ( 32752121) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) White blood cell count ( 21738480 20139978)	Major depressive disorder ( 29317602)
Interacting Genes		37 interacting genes: ASPH ATXN1L BAG6 BANP CCHCR1 CEP55 CSTF2 CSTF2T CTNNA3 DESI1 EIF3F ENKD1 EXOC8 FAM9B HGS HPCAL4 ITPRIPL1 KCNIP3 KLK7 LCN2 NCS1 NELFCD PARVG PLVAP PRKAB2 SGTA SGTB SMARCD1 TGM7 TRIM69 TSGA10 UBQLN1 UBQLN2 UBQLN4 UCHL5 VSNL1 ZDHHC17	7 interacting genes: CDSN SGTA SGTB TRAF2 UBQLN1 UBQLN2 UBQLN4
Entrez ID		1041	150771
HPRD ID		03998	13893
Ensembl ID		ENSG00000204539	ENSG00000198885
Uniprot IDs		Q15517	Q6GPH6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding TRC Complex Protein Targeting To ER Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Endoplasmic Reticulum ERAD Pathway Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Centriole Protein Targeting To Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane MRNA Cleavage And Polyadenylation Specificity Factor Complex Molecular Adaptor Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasome Binding Autophagosome Proteolysis Regulation Of Macroautophagy Localization Within Membrane Protein Targeting Protein Binding Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Establishment Of Protein Localization Cytoplasm	Positive Regulation Of ERAD Pathway TRC Complex Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Regulation Of Proteolysis Identical Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Macroautophagy Positive Regulation Of Proteolysis Protein Catabolic Process Protein Targeting To ER Positive Regulation Of Protein Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Autophagy Catabolic Process Protein Targeting To Membrane Regulation Of Autophagy Negative Regulation Of Catabolic Process Negative Regulation Of Cornification TORC2 Complex Disassembly Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Assembly Proteolysis Proteasomal Protein Catabolic Process Corneocyte Desquamation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process
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