HAGH and TERF2IP

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		HAGH	TERF2IP
Gene Name		hydroxyacylglutathione hydrolase	telomeric repeat binding factor 2, interacting protein
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Extracellular Vesicular Exosome	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mre11 Complex
	Molecular Function	Hydroxyacylglutathione Hydrolase Activity Zinc Ion Binding	Protein Binding Telomeric DNA Binding
	Biological Process	Glutathione Biosynthetic Process	Telomere Maintenance Transcription, DNA-templated Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs		Glutathione S-(N-Hydroxy-N-Bromophenylcarbamoyl)Glutathione
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP BST2 MYOC TERF2IP	125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPKOW HAAO HAGH HDGFRP3 HIST1H1A HIST1H2AL HIST1H4B HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414
Entrez ID		3029	54386
HPRD ID		00731	05452
Ensembl ID		ENSG00000063854	ENSG00000166848
Uniprot IDs		E7EN93 Q16775	Q9NYB0
PDB IDs		1QH3 1QH5 2F50	1FEX 3K6G
Enriched GO Terms of Interacting Partners?		Neuron Maturation Positive Regulation Of Intracellular Signal Transduction ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Skeletal Muscle Hypertrophy Negative Regulation Of DNA Recombination At Telomere Regulation Of Signal Transduction Regulation Of Organelle Organization Cell Maturation Regulation Of Signaling ERBB2 Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Dendritic Cell Cytokine Production Synaptic Growth At Neuromuscular Junction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Collateral Sprouting In Absence Of Injury Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Collateral Sprouting Axon Midline Choice Point Recognition Protection From Non-homologous End Joining At Telomere Negative Regulation Of Peptidase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Non-canonical Wnt Signaling Pathway Via JNK Cascade Protein Localization To Chromosome, Telomeric Region Axon Choice Point Recognition Non-canonical Wnt Signaling Pathway Via MAPK Cascade Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Proteolysis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Protein Processing Neuron Remodeling Skeletal Muscle Adaptation Regulation Of Endopeptidase Activity Regulation Of Intracellular Signal Transduction Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Actin Filament-based Process Regulation Of Peptidase Activity Negative Regulation Of Stress Fiber Assembly Neuronal Ion Channel Clustering Regulation Of Cellular Component Organization Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cellular Metabolic Process	Chromosome Organization Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Organelle Organization Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process DNA Conformation Change Chromatin Modification Cell Cycle Cellular Response To Stress DNA Metabolic Process Cellular Response To DNA Damage Stimulus Sequestering Of Actin Monomers DNA Recombination Telomere Maintenance Via Telomere Lengthening Catabolic Process DNA Duplex Unwinding Cellular Aldehyde Metabolic Process Cellular Hyperosmotic Salinity Response DNA Geometric Change DNA Replication Energy Reserve Metabolic Process Nucleosome Organization Organophosphate Catabolic Process Response To Stress Chromatin Assembly Or Disassembly Deoxyribose Phosphate Catabolic Process Cellular Localization Cellular Metabolic Process Protein Localization To Nucleus Glycogen Metabolic Process Nucleocytoplasmic Transport Chromatin Remodeling Base-excision Repair Cellular Response To X-ray Nuclear Transport Aromatic Compound Catabolic Process Nucleosome Assembly Deoxyribonucleotide Catabolic Process DNA Strand Elongation Involved In DNA Replication Small Molecule Metabolic Process DNA Strand Elongation Biosynthetic Process Chromatin Assembly Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Transport Energy Derivation By Oxidation Of Organic Compounds
Tagcloud ?		2alpha aging copy e2f4 element enhancer fungi glo1 glo2 glycation glyoxalase hotspot hydrolase hydroxyacylglutathione inducers ire isoform malaria markedly mathematical methylglyoxal modelling mre multidrug pathogenic permeant pharmacological predicts sustain	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Difference) ?		2alpha aging copy e2f4 element enhancer fungi glo1 glo2 glycation glyoxalase hotspot hydrolase hydroxyacylglutathione inducers ire isoform malaria markedly mathematical methylglyoxal modelling mre multidrug pathogenic permeant pharmacological predicts sustain	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Intersection) ?