HAGH and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
HPRD (two hybrid)

		HAGH	MYOC
Gene Name		hydroxyacylglutathione hydrolase	myocilin, trabecular meshwork inducible glucocorticoid response
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Hydroxyacylglutathione Hydrolase Activity Zinc Ion Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Glutathione Biosynthetic Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Drugs		Glutathione S-(N-Hydroxy-N-Bromophenylcarbamoyl)Glutathione
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP BST2 MYOC TERF2IP	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		3029	4653
HPRD ID		00731	03387
Ensembl ID		ENSG00000063854	ENSG00000034971
Uniprot IDs		E7EN93 Q16775	Q99972
PDB IDs		1QH3 1QH5 2F50
Enriched GO Terms of Interacting Partners?		Neuron Maturation Positive Regulation Of Intracellular Signal Transduction ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Skeletal Muscle Hypertrophy Negative Regulation Of DNA Recombination At Telomere Regulation Of Signal Transduction Regulation Of Organelle Organization Cell Maturation Regulation Of Signaling ERBB2 Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Dendritic Cell Cytokine Production Synaptic Growth At Neuromuscular Junction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Collateral Sprouting In Absence Of Injury Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Collateral Sprouting Axon Midline Choice Point Recognition Protection From Non-homologous End Joining At Telomere Negative Regulation Of Peptidase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Non-canonical Wnt Signaling Pathway Via JNK Cascade Protein Localization To Chromosome, Telomeric Region Axon Choice Point Recognition Non-canonical Wnt Signaling Pathway Via MAPK Cascade Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Proteolysis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Protein Processing Neuron Remodeling Skeletal Muscle Adaptation Regulation Of Endopeptidase Activity Regulation Of Intracellular Signal Transduction Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Actin Filament-based Process Regulation Of Peptidase Activity Negative Regulation Of Stress Fiber Assembly Neuronal Ion Channel Clustering Regulation Of Cellular Component Organization Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cellular Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		2alpha aging copy e2f4 element enhancer fungi glo1 glo2 glycation glyoxalase hotspot hydrolase hydroxyacylglutathione inducers ire isoform malaria markedly mathematical methylglyoxal modelling mre multidrug pathogenic permeant pharmacological predicts sustain	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		2alpha aging copy e2f4 element enhancer fungi glo1 glo2 glycation glyoxalase hotspot hydrolase hydroxyacylglutathione inducers ire isoform malaria markedly mathematical methylglyoxal modelling mre multidrug pathogenic permeant pharmacological predicts sustain	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?