HAGH and BST2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		HAGH	BST2
Name		hydroxyacylglutathione hydrolase	bone marrow stromal cell antigen 2
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Cytoplasm Endosome Late Endosome Multivesicular Body Golgi Apparatus Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome Side Of Membrane
	Molecular Function	Hydroxyacylglutathione Hydrolase Activity Protein Binding Hydrolase Activity Metal Ion Binding	RNA Binding Protein Binding Metalloendopeptidase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Glutathione Metabolic Process Glutathione Biosynthetic Process Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione	Immune System Process Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Response To Virus Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Response To Type II Interferon Response To Interferon-alpha Response To Interferon-beta B Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Intracellular Transport Of Viral Material
Pathways		None	Neutrophil degranulation Interferon alpha/beta signaling SARS-CoV-1 activates/modulates innate immune responses
Drugs		Glutathione S-(N-hydroxy-N-bromophenylcarbamoyl)glutathione	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: TIMM10	2 novel interactors: GATAD2A WT1
Interacting Genes		6 interacting genes: APOBEC3A APP BST2 MYOC SHANK3 TERF2IP	3 interacting genes: CD81 HAGH HARS2
Entrez ID		3029	684
HPRD ID		00731	02759
Ensembl ID		ENSG00000063854	ENSG00000130303
Uniprot IDs		H3BPQ4 Q16775	A0A024R7H5 Q10589
PDB IDs		1QH3 1QH5	2LK9 2X7A 2XG7 3MQ7 3MQ9 3MQB 3MQC 3NWH 4P6Z 6CM9 6CRI 6D83 6D84 6DFF 7Q9A
GO Terms Enriched among Interactors		Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Frizzled Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Viral Genome Replication Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Negative Regulation Of Actin Filament Bundle Assembly Skeletal Muscle Hypertrophy Mitochondrial Intermembrane Space Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Positive Regulation Of Cellular Component Organization Associative Learning Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Membrane Potential Positive Regulation Of JNK Cascade Neuron Projection Development Positive Regulation Of Intracellular Signal Transduction Lipoprotein Particle Mitochondrial Inner Membrane Positive Regulation Of Protein Import Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Dendritic Cell Cytokine Production Regulation Of Organelle Organization Negative Regulation Of DNA Recombination At Telomere Guanylate Kinase-associated Protein Clustering Regulation Of Viral Life Cycle Regulation Of Cellular Component Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import	Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Myoblast Fusion Involved In Skeletal Muscle Regeneration Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Negative Regulation Of Female Gonad Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Histidine-tRNA Ligase Activity Histidyl-tRNA Aminoacylation Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis MHC Class II Protein Binding Humoral Immune Response Mediated By Circulating Immunoglobulin Osteoclast Fusion Methylglyoxal Metabolic Process Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination S-shaped Body Morphogenesis Double-stranded Methylated DNA Binding Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process In The Vacuole Diaphragm Development Regulation Of Female Gonad Development Positive Regulation Of Male Gonad Development Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Positive Regulation Of T-helper 2 Cell Cytokine Production Tetraspanin-enriched Microdomain Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Transferrin Receptor Binding Immunological Synapse Formation Positive Regulation Of Receptor Clustering Positive Regulation Of Inflammatory Response To Antigenic Stimulus Glutathione Biosynthetic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Metanephric Epithelium Development Muscle Cell Fate Commitment Nephron Tubule Morphogenesis Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation